Evidence map›Paper›PMID 42387428›Full record

ArticleBMC cancer2026

Complications and survival after Ivor Lewis esophagectomy.

A Abu Hejleh, J Lemties, I Kreutzer, N M Wirsik, D T Krauss, S Torabi, J-O Jung, W Schröder, H A Schlößer, T Schmidt and 3 more

Abstract read
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In one paragraph

Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

A Abu HejlehDepartment of General, Visceral, Thoracic and Transplantation Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
J LemtiesDepartment of General, Visceral, Thoracic and Transplantation Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
I KreutzerDepartment of General, Visceral, Thoracic and Transplantation Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
N M WirsikDepartment of General, Visceral, Thoracic and Transplantation Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
D T KraussDepartment of General, Visceral, Thoracic and Transplantation Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
S TorabiDepartment of Anesthesiology and Intensive Care Medicine, Medical Faculty of Cologne University, University Hospital of Cologne, Cologne, Germany.
J-O JungDepartment of General, Visceral, Thoracic and Transplantation Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
W SchröderDepartment of General, Visceral, Thoracic and Transplantation Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
H A SchlößerDepartment of General, Visceral, Thoracic and Transplantation Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
T SchmidtDepartment of General, Visceral, Thoracic and Transplantation Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
H F FuchsDepartment of General, Visceral, Thoracic and Transplantation Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
C J BrunsDepartment of General, Visceral, Thoracic and Transplantation Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
L M SchiffmannDepartment of General, Visceral, Thoracic and Transplantation Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. lars.schiffmann@uk-koeln.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEsophagectomy (OE) remains a complex procedure with a considerable risk of severe postoperative complications. There is conflicting evidence if major postoperative complications impair long-term oncological survival. This retrospective study was designed to retest the hypothesis that complications after OE impact on long-term survival in a large and highly standardized cohort of esophageal cancer patients. MATERIALS AND

methods733 patients who underwent Ivor Lewis esophagectomy (IL-OE) for cancer from 2016 to 2021 at our tertiary center were analysed from a prospectively maintained database. Postoperative complications were correlated to overall survival.

resultsNeither occurrence of major complications ≥ Clavien-Dindo (CD) IIIB (Median OS not reached in both groups, p = 0.45, HR 1.12) nor AL (Median OS not reached for no AL vs. 50 months for AL, p = 0.49, HR 0.96) nor pulmonary complications (Median OS not reached in both groups, p = 0.61, HR 0.76) had an impact on overall survival. However, the necessity for postoperative readmission to ICU (reaICU) had a significant impact on overall survival (Median OS not reached for no reaICU vs. 40 months for reaICU, p = 0.037, HR 1.54). Mean follow up was 27 months.

conclusionAmong all variables, only ICU readmission significantly affected overall survival. Postoperative complications and in particular anastomotic leakage after IL-OE, per se, may have a less significant impact on overall survival than previously anticipated. This might be due to a highly sufficient management of complications that progressively avoids requirement of severe septic complications and intensive care treatment.

Indexed as

Esophageal NeoplasmsEsophagectomyPostoperative ComplicationsAgedFemaleHumansMaleMiddle AgedPatient ReadmissionRetrospective StudiesAnastomotic leakComplicationsEsophagectomyIvor LewisSurvival

Identifiers

PMID42387428
PMCPMC13326540

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.