SynthesisBMC cancer2026
The impact of abiraterone and enzalutamide on hypokalemia incidence in patients with prostate cancer: a systematic review and meta-analysis.
Synthesis in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo systematically evaluate the incidence of hypokalemia associated with novel androgen receptor axis-targeted therapies (ARATs)-specifically abiraterone, enzalutamide, and their combination-in patients with advanced prostate cancer.
methodsA comprehensive search of PubMed, Embase, and the Cochrane Library was conducted to identify published randomized controlled trials (RCTs). Risk of bias was assessed using the Cochrane Risk of Bias tool. A random-effects model was employed to pool risk ratios (RRs) and 95% confidence intervals (CIs). Heterogeneity was quantified using the I
resultsEight unique RCTs (comprising 9 published reports) involving 9,298 patients were included. The overall pooled analysis demonstrated a significantly increased risk of all-grade hypokalemia in patients receiving ARATs compared to controls (RR = 3.11, 95% CI: 1.88-5.15, P < 0.001; I
conclusionBased on our preliminary findings, ARAT therapies, particularly abiraterone and combination regimens, are significantly related to the increased risk of hypokalemia in patients with advanced prostate cancer. Vigilant monitoring and the proactive management of serum potassium levels are strongly warranted in clinical practice.
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