Evidence map›Paper›PMID 42387403›Full record

ArticleBMC cardiovascular disorders2026

Measuring left ventricular global longitudinal strain in different contrast-enhanced echocardiography modes: a feasibility study.

Jiali Zhu, Yajing Miao, Hong Zhou, Gaojie Han, Jing Wang, Qiaoli Tong, Xuqian Zhang, Xiaoxu Wang, Hongning Yin

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Jiali ZhuDepartment of Ultrasound, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yajing MiaoDepartment of Echocardiography, the Second Hospital of Hebei Medical University, Shijiazhuang, China.
Hong ZhouDepartment of Echocardiography, the Second Hospital of Hebei Medical University, Shijiazhuang, China.
Gaojie HanDepartment of Echocardiography, the Second Hospital of Hebei Medical University, Shijiazhuang, China.
Jing WangDepartment of Echocardiography, the Second Hospital of Hebei Medical University, Shijiazhuang, China.
Qiaoli TongDepartment of Echocardiography, the Second Hospital of Hebei Medical University, Shijiazhuang, China.
Xuqian ZhangDepartment of Echocardiography, the Second Hospital of Hebei Medical University, Shijiazhuang, China.
Xiaoxu WangDepartment of Echocardiography, the Second Hospital of Hebei Medical University, Shijiazhuang, China.
Hongning YinDepartment of Echocardiography, the Second Hospital of Hebei Medical University, Shijiazhuang, China. eveningyhn@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeft ventricular global longitudinal strain (LVGLS) is an important parameter to evaluate left ventricular (LV) systolic function, which is more sensitive and reproducible than left ventricular ejection fraction (LVEF). However, whether LVGLS can be accurately measured with ultrasound enhancing agent (UEA) remains controversial. The aim of this study was to verify the feasibility and reproducibility of LVGLS in different contrast-enhanced echocardiography (CE) modes.

methodsTwo-dimensional speckle tracking echocardiography (2D-STE) was used to measure LVGLS on 75 patients included in this study. Patients were divided into optimal group (n = 33) and suboptimal group (n = 42) according to image quality. LVGLS measurements were performed in 2D mode, left ventricular opacification (LVO) mode, and myocardial contrast echocardiography (MCE) mode. 2D mode LVGLS measurements of the optimal group were used as a reference standard. The comparisons among different modes of each group included Bland-Altman analysis, linear regression and intra-class correlation (ICC). 20 patients were randomly selected from each group to analyze the inter- and intra-observer variability.

resultsThe LVO and MCE modes of optimal group had similar LVGLS measurements with 2D mode (-14.30 ± 4.73%

conclusionsIt is feasible to measure LVGLS in different CE modes, even in patients with suboptimal acoustic windows, which can reduce the impact of image quality on LVGLS measurements.

Indexed as

Contrast MediaEchocardiographyGlobal Longitudinal StrainPhospholipidsSulfur HexafluorideVentricular Dysfunction, LeftVentricular Function, LeftAgedFeasibility StudiesFemaleHumansMaleMiddle AgedObserver VariationPredictive Value of TestsReproducibility of ResultsContrast MediaPhospholipidsSulfur HexafluorideContrast-enhanced echocardiographyLeft ventricular global longitudinal strainMyocardial deformationSpeckle tracking

Identifiers

PMID42387403
PMCPMC13591883

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