ArticleBMC microbiology2026
Solvent alternation of the antimicrobial, antioxidant, anticancer activities and chemical profiles of Trametes hirsuta (Wulfen) Lloyd.
Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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4 authors.
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Abstract
backgroundThe exploration for sustainable bioresources with a wide range of therapeutic potential is vital due to the expanding incidence of cancer and the rapid development of drug-resistant pathogens. By combining solvent-dependent extraction efficiency with antimicrobial, antifungal, anticancer, antioxidant, and Mycochemical analysis, our study offers a thorough assessment of Trametes hirsuta extracts.
methodsIn our study, the antimicrobial, anticancer, cytotoxic, and antioxidant properties of Trametes hirsuta extracts made with water (H₂O), ethanol (EtOH), acetone (Ace), ethyl acetate (EtOAc), and chloroform (CF) were assessed in this investigation. GC-MS and Mycochemical analysis were used to further characterize to determine their bioactive compounds.
resultsThe strongest antibacterial activity was shown by polar solvents represented by EtOH and H₂O, which produced inhibition zones up to 31.3 mm and MICs as low as 15.6 µg/mL against Streptococcus agalactiae and Enterococcus raffinosus. Trametes hirsuta extracts recorded significant antifungal activity against Aspergillus niger, Botrytis cinerea, and Alternaria alternata; EtOH and H₂O extracts once again demonstrated the lowest MIC values (15.6 µg/mL). At 50 µg/mL, the T. hirsuta EtOH extract showed the strongest antioxidant performance and strong cytotoxic activity, inhibiting almost 80% of SK-HEP-1 and PC-3 carcinoma cells. Various fatty acids, esters, sterols, and phenolic derivatives particularly linoleic acid methyl ester and n-hexadecanoic acid were establish by GC-MS profiling, and these compounds most likely support the bioactivities that have been detected. The highest concentrations of phenolics, flavonoids, tannins, and alkaloids were found in T. hirsute EtOH and H₂O extracts.
conclusionsOur results showed that solvent polarity significantly influences T. hirsuta bioactive profile and pharmacological potential, making this fungus a promising environmentally friendly bioresources for the design of natural antimicrobial and anticancer drugs.
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