Evidence map›Paper›PMID 42387357›Full record

SynthesisInternational journal of rheumatic diseases2026

The Asia Pacific League of Associations for Rheumatology (APLAR) Consensus Statements for the Management of Reproductive Issues in Autoimmune Rheumatic Diseases.

Vinod Ravindran, Madhuri H Radhakrishna, Sunitha Kayidhi, Alberta Hoi, Chen-I Hsieh, Claire Ann Marrie Barrett, Fatima Alnaimat, Jin-Su Park, Kayoko Kaneko, Latika Gupta and 6 more

Erratum issuedAbstract readConsensus StatementSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of rheumatic diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Vinod RavindranCentre for Rheumatology, Kozhikode, Keralam, India.ORCID https://orcid.org/0000-0001-5842-1877
Madhuri H RadhakrishnaDepartment of Rheumatology, Star Hospitals, Hyderabad, India.ORCID https://orcid.org/0000-0002-8054-3448
Sunitha KayidhiDepartment of Rheumatology, Continental Hospital, Hyderabad, India.ORCID https://orcid.org/0000-0001-5527-2546
Alberta HoiSchool of Clinical Sciences, Monash University, Melbourne, Australia.ORCID https://orcid.org/0000-0002-9416-7383
Chen-I HsiehChang Gung Memorial Hospital, Taoyuan City, Taiwan.ORCID https://orcid.org/0000-0003-3715-0363
Claire Ann Marrie BarrettRedcliffe Hospital, Redcliffe, Queensland, Australia.ORCID https://orcid.org/0000-0002-0362-0382
Fatima AlnaimatDepartment of Internal Medicine, Division of Rheumatology, School of Medicine, University of Jordan, Amman, Jordan.ORCID https://orcid.org/0000-0002-5574-2939
Jin-Su ParkDivision of Rheumatology, Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, Goyang, Gyeonggi-do, Republic of Korea.ORCID https://orcid.org/0000-0002-4716-1149
Kayoko KanekoDivision of Maternal Medicine, Canter for Maternal-Fetal, and Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.ORCID https://orcid.org/0000-0003-3411-5896
Latika GuptaDepartment of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK.ORCID https://orcid.org/0000-0003-2753-2990
May Ching SohMiddlemore Hospital, Counties Manukau Health New Zealand, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-7160-7550
Min Kyung ChungDivision of Rheumatology, Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0001-6414-9187
Ratchaya LertnawapanDivision of Rheumatology, Department of Medicine, Thammasat University, Bangkok, Thailand.ORCID https://orcid.org/0000-0003-1190-2782
Samar Al EmadiMedicine Department, Rheumatology Section, Hamad Medical Corporation, Doha, Qatar.ORCID https://orcid.org/0000-0001-7942-4831
Saira Elaine Anwer KhanShalamar Hospital, Shalamar Medical and Dental College, Lahore, Pakistan.ORCID https://orcid.org/0000-0003-3223-4787
Uthpala DissanayakeNational Hospital, Kandy, Sri Lanka.ORCID https://orcid.org/0009-0009-9048-2296

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe management of reproductive health in individuals with autoimmune rheumatic diseases (AIRDs) has evolved into a primary clinical priority. Wide variations in clinical practice and drug availability in the Asia-Pacific regions necessitate localized frameworks. These consensus statements, developed by the Asia Pacific League of Associations for Rheumatology (APLAR) Special Interest Group for Women's Health & Reproductive Issues in Rheumatic and Musculoskeletal Diseases, aim to bridge the gaps within the region, foster multidisciplinary collaboration, and address regional knowledge deficits.

methodsAn expert panel comprising 16 members of the 13 APLAR member nation organizations formulated 23 research questions using the PICO framework. A systematic review of English-language literature up to July 2025 was conducted across the MEDLINE, Scopus, Google Scholar, and Cochrane Library databases, supplemented by a manual search of journals from the APLAR regions. Evidence from the APLAR region was appraised using the GRADE system. A modified Delphi online voting process was employed to reach consensus, pre-defined as ≥ 75% agreement.

resultsThe panel approved four overarching principles and 86 statements, organized into 16 broad categories. These statements cover all three phases of pregnancy in AIRDs, the safety of medications during pregnancy and lactation, contraception, assisted reproductive techniques, fertility preservation, and hormonal replacement therapy, covering both female and male aspects as relevant.

conclusionIn a field often lacking high-quality data, these consensus statements from APLAR provide expert opinion-based guidance to support clinical decision-making. It is envisaged that it will assist in educational and training purposes and help shape future research priorities.

Indexed as

Autoimmune DiseasesPregnancy ComplicationsReproductive HealthRheumatic DiseasesRheumatologyAntirheumatic AgentsAsiaFemaleHumansMalePregnancyReproductive Techniques, AssistedAntirheumatic Agentsconceptionmedicines during pregnancymultidisciplinarypregnancyreproductiverheumatic diseasessystemic lupus erythematosus

Identifiers

PMID42387357
PMCPMC13379808

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.