Evidence map›Paper›PMID 42387353›Full record

ArticleBMC women's health2026

The association between dietary acid load and endometriosis: a case-control study.

Morvarid Noormohammadi, Seyed Mojtaba Ghoreishy, Sakine Ghasemisedaghat, Fatemeh Sadat Hashemi Javaheri, Ghazaleh Eslamian, Seyyedeh Neda Kazemi, Bahram Rashidkhani, Robabeh Taheripanah, Mehran Nouri

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Article in BMC women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Morvarid NoormohammadiGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyed Mojtaba GhoreishyStudent Research Committee, Faculty of Public Health Branch, Iran University of Medical Sciences, Tehran, Iran.
Sakine GhasemisedaghatDepartment of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, P.O.Box: 19395-4741, No 7, Hafezi St., Farahzadi Blvd, Tehran, 1981619573, Iran.
Fatemeh Sadat Hashemi JavaheriDepartment of Clinical Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Ghazaleh EslamianDepartment of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, P.O.Box: 19395-4741, No 7, Hafezi St., Farahzadi Blvd, Tehran, 1981619573, Iran. gh.eslamian@sbmu.ac.ir.
Seyyedeh Neda KazemiDepartment of Obstetrics and Gynecology, School of Medicine, Preventative Gynecology Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Bahram RashidkhaniDepartment of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Robabeh TaheripanahDepartment of Obstetrics and Gynecology, School of Medicine, Men's Health and Reproductive Health Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mehran NouriInfertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. mehran_nouri71@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndometriosis is a chronic inflammatory disorder that affects 5-15% of women of reproductive age. It is characterized by severe symptoms, including dysmenorrhea and non-cyclic pelvic pain, which can substantially impair quality of life. Although diet is a major modifiable risk factor for many chronic diseases, its potential role in endometriosis has received limited attention. This study aimed to investigate the association between Dietary Acid Load (DAL) and the odds of endometriosis among Iranian women.

methodsThis hospital-based case-control study was conducted in Tehran, Iran, between February to September 2021. Participants included women diagnosed with endometriosis and healthy controls, all of whom were evaluated by a gynecologist who was blinded to the study object. Dietary intake was assessed using a validated 168-item food frequency questionnaire (FFQ). DAL was estimated using Two indices: Potential Renal Acid Load (PRAL) and Net Endogenous Acid Production (NEAP). Logistic regression models were used to investigate the association between DAL and odds of endometriosis.

resultsA total of 105 women with endometriosis and 208 healthy controls were included in the study. The results showed that each one-unit increase in PRAL and NEAP was associated with an 8%, and 4% increase in the odds of endometriosis, respectively.

conclusionHigher DAL was associated with increased odd of endometriosis. These findings suggest that reducing the consumption of acid-producing foods may help lower the risk of endometriosis. Further prospective studies are warranted to confirm these findings and clarify the underlying mechanisms.

Indexed as

AcidsDietEndometriosisAdultCase-Control StudiesFemaleHumansIranRisk FactorsSurveys and QuestionnairesYoung AdultAcidsCase-control studyDietDietary acid loadEndometriosisNet endogenous acid productionPotential renal acid load

Identifiers

PMID42387353
PMCPMC13595638

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