ArticleThoracic cancer2026
The Impact of Immunotherapy on Hair Repigmentation in Patients With Thoracic Tumors: A Clinical Observation Based on Trichoscopy.
Article in Thoracic cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveWhether hair repigmentation during cancer therapy is driven by immune checkpoint inhibitors (ICIs) or chemotherapy remains unclear. This study aimed to quantitatively identify the primary driver using a controlled design.
methodsIn this prospective study, 29 patients with thoracic malignancies were divided into an immunotherapy group (n = 18) and a chemotherapy group (n = 11). Standardized dermoscopic images were captured before and after treatment. Hair pigmentation was quantified via grayscale analysis.
resultsGrayscale values decreased significantly posttreatment in the immunotherapy group (p = 0.0008) but not in the chemotherapy group (p = 0.1427). The magnitude of change (ΔGrayscale) was significantly greater with immunotherapy than with chemotherapy alone (23.5 ± 24.67 vs. 4.32 ± 9.01; p = 0.0065), representing a large effect size (Cohen's d = 0.90).
conclusionThis controlled study provides quantitative evidence suggesting that immunotherapy, rather than chemotherapy, is closely associated with hair repigmentation. It establishes an objective methodological framework for future investigation of this phenomenon.
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