Evidence map›Paper›PMID 42387102›Full record

ArticleMolecular psychiatry2026

The neurodevelopmental spectrum: phenotypic architecture, etiology, predictive utility, and specificity across development.

Giorgia Michelini, Wangjingyi Liao, Shiqi D Lu, Chiara Caserini, Thalia C Eley, Angelica Ronald, Sylia Wilson, Margherita Malanchini, Kaili Rimfeld

Abstract read
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In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giorgia MicheliniCentre for Brain and Behaviour, Department of Psychology, School of Biological & Behavioural Science, Queen Mary University of London, London, UK. g.michelini@qmul.ac.uk.ORCID http://orcid.org/0000-0002-0887-7582
Wangjingyi LiaoCentre for Brain and Behaviour, Department of Psychology, School of Biological & Behavioural Science, Queen Mary University of London, London, UK.
Shiqi D LuCentre for Brain and Behaviour, Department of Psychology, School of Biological & Behavioural Science, Queen Mary University of London, London, UK.
Chiara CaseriniCentre for Brain and Behaviour, Department of Psychology, School of Biological & Behavioural Science, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-7585-8920
Thalia C EleySocial, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-6458-0700
Angelica RonaldSchool of Psychology, University of Surrey, Guildford, UK.ORCID http://orcid.org/0000-0002-9576-2176
Sylia WilsonInstitute of Child Development, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-0144-524X
Margherita MalanchiniCentre for Brain and Behaviour, Department of Psychology, School of Biological & Behavioural Science, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-7257-6119
Kaili RimfeldSocial, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-5139-065X

Funding

Klingenstein Third Generation Foundation (KTGF) 20212999RCUK | Medical Research Council (MRC) G1100559RCUK | Medical Research Council (MRC) MR/V012878/1, MR/M021475/1RCUK | Medical Research Council (MRC) UKRI1503RCUK | Medical Research Council (MRC) UKRI1506Wellcome Trust (Wellcome) 213514/Z/18/Z
6 · The paper itself

Abstract

Neurodevelopmental conditions are highly heritable, heterogeneous, and frequently co-occur. Transdiagnostic dimensional approaches have advanced understanding and classification of psychiatric disorders, but have largely omitted neurodevelopmental conditions. Using longitudinal data for >10,000 children from the Twins Early Development Study, we investigated the structure of a transdiagnostic "neurodevelopmental spectrum" across development, its etiology, its ability to predict functional outcomes, and the specificity of these associations. Hierarchical exploratory factor modeling of a broad set of traits/symptoms delineated a neurodevelopmental spectrum encompassing neurodevelopmental traits at ages 7, 12, and 16. This spectrum emerged as a distinct dimension alongside separable dimensions of internalizing, externalizing, and psychosis symptoms. The neurodevelopmental spectrum was highly heritable across development in twin analyses (h

Identifiers

PMID42387102

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.