Evidence map›Paper›PMID 42387065›Full record

ArticleCell death and differentiation2026

SETD7 depletion enhances white adipose browning and ameliorates metabolic disorders in obese mice.

Chenxi Xiao, Yajie Hu, Jiayao Liu, Jialin Zhao, Jie Xu, Honghong Chen, Qiuyuan Huang, Wugui Chen, Jun Chang, Xinhua Liu and 1 more

Abstract read
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In one paragraph

Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chenxi Xiao *Department of Orthopaedics, Mindong Hospital, Fujian Medical University, Fuzhou, China.
Yajie Hu *Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai, China.
Jiayao Liu *Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai, China.
Jialin ZhaoPharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai, China.
Jie XuPharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai, China.
Honghong ChenPharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai, China.
Qiuyuan HuangPharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai, China.
Wugui ChenDepartment of Orthopaedics, Mindong Hospital, Fujian Medical University, Fuzhou, China. cwg@fjmu.edu.cn.ORCID http://orcid.org/0009-0001-1119-1987
Jun ChangDepartment of Orthopaedics, Mindong Hospital, Fujian Medical University, Fuzhou, China. jchang@fudan.edu.cn.ORCID http://orcid.org/0000-0001-6481-7130
Xinhua LiuDepartment of Orthopaedics, Mindong Hospital, Fujian Medical University, Fuzhou, China. liuxinhua@fudan.edu.cn.ORCID http://orcid.org/0000-0002-9972-8215
Chengshou LinDepartment of Orthopaedics, Mindong Hospital, Fujian Medical University, Fuzhou, China. lcsmindong@fjmu.edu.cn.ORCID http://orcid.org/0009-0006-6876-9635

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity, a major global health challenge associated with metabolic and cardiovascular disorders, has drawn increasing attention to the therapeutic potential of white adipose tissue (WAT) browning. Although the lysine methyltransferase SETD7 has been implicated in various cardiovascular and metabolic diseases, its role in adipose thermogenesis remains unclear. Here, we reported that SETD7 was upregulated in inguinal WAT (iWAT) of obese mice and was primarily localized to mature adipocytes. Setd7 knockdown (Setd7

Identifiers

PMID42387065

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.