Evidence map›Paper›PMID 42387031›Full record

SynthesisJournal of neurology2026

Cerebral amyloid angiopathy-related inflammation (CAA-ri): an updated systematic review and meta-analysis.

Vincenzo Laterza, Giuseppe Magro, Federico Tosto, Andrea Quattrone

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vincenzo LaterzaDepartment of Neuroscience, "Di Venere Hospital", Via Ospedale di Venere 1, Bari, Italy. vincenzo.laterza.md@gmail.com.ORCID http://orcid.org/0009-0003-9603-823X
Giuseppe MagroDepartment of Neuroscience, "Giovanni Paolo II" Hospital, Lamezia Terme, Catanzaro, Italy.ORCID http://orcid.org/0000-0002-8187-8354
Federico TostoDepartment of Neuroscience, "Giovanni Paolo II" Hospital, Lamezia Terme, Catanzaro, Italy.ORCID http://orcid.org/0000-0002-1802-8840
Andrea QuattroneNeuroscience Research Center, Magna Graecia University, Catanzaro, Italy.ORCID http://orcid.org/0000-0003-2001-957X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare subtype of CAA, and it is correlated with pathological evidence of inflammation against amyloid-β in the walls of blood vessels and the surrounding tissue. Limited data exist on the prevalence of clinical, neuroimaging, and genetic characteristics in CAA-ri.

methodA systematic review and meta-analysis pooled data from published studies on CAA-ri. Random-effects models were used to calculate pooled prevalence rates, and heterogeneity was assessed using I

resultsWe identified 4 prospective and 22 retrospective cohort studies comprising 553 patients with CAA-ri (mean age, 70.9 years; women, 51.29%). Prevalence rates were: cognitive decline at presentation 66% ([95% CI 50-80%]; I

conclusionsCognitive decline and focal neurological deficits were the most common clinical features, while lobar cerebral microbleeds were the predominant neuroimaging finding. Forty-two percent of patients carried the homozygous APOE ε4/ε4 genotype, seventy-nine percent underwent steroid therapy, and favorable outcomes were observed in seventy-five percent of cases.

Indexed as

Cerebral Amyloid AngiopathyInflammationNeuroinflammatory DiseasesHumansAPOE-E ε4Cerebral amyloid angiopathy–related inflammationMeta-analysisSystematic review

Identifiers

PMID42387031

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.