ArticleZeitschrift fur Gerontologie und Geriatrie2026
Effect of anticholinergic burden on cardiac functions in older patients.
Article in Zeitschrift fur Gerontologie und Geriatrie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study investigated the detrimental effects of a high anticholinergic burden on both myocardial systolic-diastolic functions and electrical functions in older adults.
methodsA total of 24 patients with a high anticholinergic burden and 26 control patients were enrolled. The anticholinergic burden was assessed using the anticholinergic burden (ACB) scale. An ACB of ≥ 2 was categorized as high anticholinergic burden, while those with an ACB score of 0 were included in the control group. Each participant's diastolic and systolic functions were evaluated using transthoracic two-dimensional, conventional and tissue Doppler echocardiography. Heart rate and corrected QT interval (cQT) were also measured to assess electrophysiological changes.
resultsThe mean age was 72.5 ± 6.6 years. Biventricular systolic and diastolic functions were impaired in the high ACB patients. Systolic function parameters such as lateral‑S (8.04 ± 1.43 vs. 9.54 ± 1.82, p = 0.003), septal‑S (7.33 ± 0.64 vs. 8.27 ± 1.31, p = 0.007) and tricuspid‑S (12.42 ± 1.72 vs. 14.31 ± 3.17, p = 0.025) values were lower in the ACB patients compared to the control group. The indicator of left ventricular (LV) filling pressure (E/E') was higher in ACB patients than in the controls (11.61 ± 2.89 vs. 8.83 ± 1.68, p < 0.001). There was no significant difference in terms of heart rate and cQT. Serum albumin levels were lower in ACB patients comparing to controls (4.08 ± 0.33 vs. 4.38 ± 0.27, p = 0.001).
conclusionA high anticholinergic burden is associated with moderately impaired systolic and diastolic functions, yet on its own, it does not sufficiently explain the increased hospitalization and mortality observed in older adults.
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