Evidence map›Paper›PMID 42386981›Full record

ArticleNature2026

TROP2 targeting reveals therapy-driven cell state dynamics in colorectal cancer.

Nuria Vaquero-Siguero, Nikolaos Georgakopoulos, Maria C Puschhof, Ioannis Chiotakakos, Jasmin Meier, Sigrid K Fey, Gabriele Diamante, Manuel Mastel, Aitana Guiseris-Martinez, Guillaume Belthier and 21 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Nuria Vaquero-Siguero *Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
Nikolaos Georgakopoulos *Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
Maria C Puschhof *Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.ORCID http://orcid.org/0000-0003-2866-9155
Ioannis ChiotakakosHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.ORCID http://orcid.org/0009-0007-6973-3842
Jasmin MeierHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
Sigrid K FeyHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
Gabriele DiamanteHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
Manuel MastelHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
Aitana Guiseris-MartinezHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
Guillaume BelthierDivision of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Nikolai SchleußnerHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
Julia VolkHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
Carolin ArtmannHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.
Bryce LimDivision of Cell Fate Engineering and Disease Modeling, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-5688-3952
Ronald KoschnyInterdisciplinary Endoscopy Center (IEZ)/Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany.
Cyrill WehlingInterdisciplinary Endoscopy Center (IEZ)/Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany.
Kyanna S OuyangFaculty of Biosciences, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0009-0007-1198-1405
Michael GüntherInstitute of General Pathology, Medical University Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0009-0001-5091-5060
Solveig KussInstitute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-2363-8475
Paula HoffmeisterDepartment of Medical Oncology, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.
Moritz MallDivision of Cell Fate Engineering and Disease Modeling, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-1278-2594
Jens NeumannInstitute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Steffen OrmannsInstitute of General Pathology, Medical University Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-0754-9034
Martin SchneiderDepartment of General, Visceral and Transplant Surgery, University Hospital of Heidelberg, Heidelberg, Germany.
Thomas SchmidtDepartment of General, Visceral and Transplant Surgery, University Hospital of Heidelberg, Heidelberg, Germany.
Jens PuschhofJunior Research Group Epithelium Microenvironment Interactions (EMIL), German Cancer Research Center, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-9275-4034
Andreas TrumppHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6212-3466
Jacco van RheenenDivision of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-8175-1647
Julio Saez-RodriguezFaculty of Medicine, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-8552-8976
Bruno C KöhlerDepartment of Medical Oncology, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-7308-0377
Rene JackstadtHeidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany. r.jackstadt@dkfz.de.ORCID http://orcid.org/0009-0005-6246-2133

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastasis remains the leading cause of cancer-related mortality and is driven by pronounced tumour cell plasticity

Indexed as

Antigens, NeoplasmCell Adhesion MoleculesColorectal NeoplasmsImmunoconjugatesMolecular Targeted TherapyAnimalsCell Line, TumorDrug Resistance, NeoplasmFemaleHumansMiceNeoplasm MetastasisNeoplastic Stem CellsPrognosisAntigens, NeoplasmCell Adhesion MoleculesImmunoconjugatesTACSTD2 protein, human

Identifiers

PMID42386981
PMCPMC13518220

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.