ArticleNature2026
Steatosis shapes prognosis-defining liver metastasis heterogeneity in CRC.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Steatosis fuels replacement liver metastases in colorectal cancer.Nature reviews. Gastroenterology & hepatology · 2026Article
- The Dynamic Alliance of p53 and Metabolism in the Tumor Microenvironment Shapes Tumor Evolution.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Preoperative CT-derived liver fat fraction and visceral adipose tissue index enhance postoperative recurrence risk stratification in colorectal cancer.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors.
Yiming Peng-WinklerLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0002-8327-559X
Xiao-Zheng Liu *Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0002-8452-6848
Sanne M L Verheul *Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-6070-6337
Charlotte Girondel *Department of Medicine, Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.
Sebastian IgelmannLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0001-6133-4184
Sara Marie RotterDepartment of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.
Michail DoukasDepartment of Pathology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-8611-840X
Ming LiuLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0003-3567-530X
Anke VandekeereLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0001-6836-3834
Mélanie PlanqueLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.
Juan Fernández-GarcíaLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0003-3422-3627
Sébastien TabarièsDepartment of Medicine, Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0003-3513-6111
Marta Buetas-ArcasRadiomics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain.ORCID http://orcid.org/0009-0004-3527-1318
Sandra Martínez-MartínPeptomyc, Barcelona, Spain.ORCID http://orcid.org/0000-0003-4443-0697
Florian DöbbeDepartment of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.
Margherita DemiccoLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0002-9396-3281
Ines VermeireLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0003-3366-7410
Janine TheileLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0009-0006-1155-7594
Johannes CeuppensLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0009-0006-2335-7733
Jonas HaesevoetsLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0009-0009-8379-3117
Emma Tobarra-LópezLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0009-0001-2331-5713
Dorien BroekaertLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0002-9777-1607
Johannes Georg BodeDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Dusseldorf, Dusseldorf, Germany.ORCID http://orcid.org/0000-0002-7141-0694
Tom LueddeDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Dusseldorf, Dusseldorf, Germany.ORCID http://orcid.org/0000-0002-6288-8821
Peter VermeulenDepartment of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Daniele V F TaurielloDepartment of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1522-3496
Raquel Perez-LopezRadiomics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain.
Steve StegenLaboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-4471-6401
Laura SoucekPeptomyc, Barcelona, Spain.ORCID http://orcid.org/0000-0002-4750-7971
Tiago De OliveiraDepartment of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0002-2502-7897
Lena-Christin ConradiDepartment of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.
Peter M SiegelDepartment of Medicine, Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-5568-6586
Cornelis VerhoefDepartment of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-9980-8613
Sarah-Maria FendtLaboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium. sarah-maria.fendt@kuleuven.be.ORCID http://orcid.org/0000-0001-6018-9296
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with colorectal cancer (CRC) frequently develop liver metastases
Indexed as
Colorectal NeoplasmsFatty LiverLiver NeoplasmsAcetylationAnimalsCollagen Type IFatty AcidsFemaleHumansMaleMiceOrganoidsOxidation-ReductionPrognosisProlineProtein StabilityCollagen Type IFatty AcidsMYC protein, humanProlineProto-Oncogene Proteins c-myc
Identifiers
PMID
42386979What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.