Evidence map›Paper›PMID 42386970›Full record

ArticleNature2026

Correcting congenital myasthenia-associated acetylcholine receptor defects.

Huanhuan Li, Nuriya Mukhtasimova, Jinfeng Teng, Elfie S Cavalli, Xilin Gu, Jason K Sello, Steven M Sine, Ryan E Hibbs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huanhuan LiDepartment of Neurobiology, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0009-0009-9958-7115
Nuriya MukhtasimovaReceptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-6652-1974
Jinfeng TengDepartment of Neurobiology, University of California, San Diego, La Jolla, CA, USA.
Elfie S CavalliDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Xilin GuDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5441-7958
Jason K SelloDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA. jason.sello@ucsf.edu.ORCID http://orcid.org/0000-0001-6263-7902
Steven M SineReceptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA. sine@mayo.edu.ORCID http://orcid.org/0000-0002-0594-6052
Ryan E HibbsDepartment of Neurobiology, University of California, San Diego, La Jolla, CA, USA. rehibbs@ucsd.edu.ORCID http://orcid.org/0000-0003-4283-1147

Funding

STRUCTURE/FUNCTION OF THE ACETYLCHOLINE RECEPTORR01NS031744 · NINDS · MAYO CLINIC ROCHESTER · PI SINE, STEVEN M · 1992 to 2023
$7.3M
Structure and Function of the Acetylcholine ReceptorR37NS031744 · NINDS · MAYO CLINIC ROCHESTER · PI SINE, STEVEN M · 2001 to 2007
$4.1M
Structural basis of nicotinic acetylcholine receptor gating and toxin inhibitionR01NS120496 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI HIBBS, RYAN E · 2021 to 2025
$3.3M
Structural mechanisms of autoimmune diseases targeting cys-loop receptorsR01NS130831 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ryan E Hibbs, NANCY L MONSON · 2023 to 2026
$2.5M
Structural mechanisms of nicotinic acetylcholine receptors in health and diseaseR37NS120496 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ryan E Hibbs · 2026 to 2026
$898k
NINDS NIH HHS R01 NS031744NINDS NIH HHS R01 NS120496NINDS NIH HHS R01 NS130831NINDS NIH HHS R37 NS031744NINDS NIH HHS R37 NS120496
6 · The paper itself

Abstract

Voluntary muscle contraction is triggered by the neurotransmitter acetylcholine binding its receptors on the postsynaptic membrane of the neuromuscular junction, opening ion channels that allow cation influx and initiate depolarization

Indexed as

Myasthenic Syndromes, CongenitalReceptors, CholinergicAllosteric SiteAnimalsCryoelectron MicroscopyFluoxetineHumansIon Channel GatingModels, MolecularMorpholinesMutationFluoxetineMorpholinesReceptors, Cholinergic

Identifiers

PMID42386970
PMCPMC13430646

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.