Evidence map›Paper›PMID 42386964›Full record

ArticleNature2026

Dual tumour-myeloid targeting of glioblastoma with GPNMB CAR-T cells.

Neil Savage, Shan Grewal, Muhammad Vaseem Shaikh, Franz J Zemp, Dillon Mckenna, Nicholas Mikolajewicz, Hinda Najem, Joanna Pyczek, Jiuran Wei, Mohamed A B Taleb and 25 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Neil Savage *Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Shan Grewal *Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Muhammad Vaseem Shaikh *Centre for Discovery in Cancer Research, McMaster University, Hamilton, Ontario, Canada.
Franz J ZempArnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Dillon MckennaCentre for Discovery in Cancer Research, McMaster University, Hamilton, Ontario, Canada.
Nicholas MikolajewiczDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Hinda NajemFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4432-9708
Joanna PyczekArnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Jiuran WeiDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Mohamed A B TalebDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-6153-8782
Lucas C AsselstineDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Alisha AnandDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Shawn C ChafeCentre for Discovery in Cancer Research, McMaster University, Hamilton, Ontario, Canada.
Kui ZhaiCentre for Discovery in Cancer Research, McMaster University, Hamilton, Ontario, Canada.
William T MaichDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Chirayu R ChokshiDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Hardikkumar PatelDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Tiegan E KormanDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0009-0005-9805-8669
Minomi SubapandithaMcMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.
Zoya TabunshchykMcMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.
Nazanin TatariDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Petar MileticCentre for Discovery in Cancer Research, McMaster University, Hamilton, Ontario, Canada.
David ChenDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Sebastian PachecoFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Abdelsimar T OmarDivision of Neurosurgery, Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-2965-8506
Bill WangDivision of Neurosurgery, Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Hong HanDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Jennifer A ChanArnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0001-9798-1551
Kevin R BrownDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-5514-2538
Chitra VenugopalCentre for Discovery in Cancer Research, McMaster University, Hamilton, Ontario, Canada.
Thomas KislingerDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-3525-5540
Amy B HeimbergerFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9970-8695
Jason MoffatDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-5663-8586
Douglas J MahoneyArnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0002-0642-992X
Sheila K SinghDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. sheila.singh@kcl.ac.uk.ORCID http://orcid.org/0000-0003-1272-5300

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma is a lethal brain tumour for which current multimodal treatment rarely prevents recurrence

Indexed as

Brain NeoplasmsEye ProteinsGlioblastomaImmunotherapy, AdoptiveMembrane GlycoproteinsMyeloid CellsReceptors, Chimeric AntigenT-LymphocytesAnimalsAntigens, NeoplasmFemaleHumansMaleMiceTumor MicroenvironmentXenograft Model Antitumor AssaysAntigens, NeoplasmEye ProteinsGPNMB protein, humanMembrane GlycoproteinsReceptors, Chimeric Antigen

Identifiers

PMID42386964
PMCPMC13518245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.