ArticleNature neuroscience2026
Goal-directed hippocampal theta sweeps during memory-guided navigation.
Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Dorsoventral gradient of theta sweeps in the medial entorhinal cortex.Science advances · 2026Article
- Decoding Medial Entorhinal Cortical Dynamics Produces Planning-Like Alternations in Hippocampal theta Sequences.Hippocampus · 2026Article
- Just how goal-directed are hippocampal theta sweeps, anyway?Nature neuroscience · 2026Article
- Cognitive maps as a medium for thought.Trends in cognitive sciences · 2026Review
- The hippocampus as a small-world cognitive map.bioRxiv : the preprint server for biology · 2026Article
- Naturalistic behavior and self-generated neural activity predictive of self-correction.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal representations differentiate reactive and anticipatory responses during foraging under threat.bioRxiv : the preprint server for biology · 2026Article
- Top-down regulation of ingestive behavior fragmentation.bioRxiv : the preprint server for biology · 2026Article
- Dynamical modulation of hippocampal replay through firing rate adaptation.Nature communications · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
During navigation, animals continuously sample their environment and plan routes to distant goals. Flexible navigation requires neural dynamics capable of rapidly deploying task-relevant information to direct behavior toward goals. Hippocampal spiking sequences within theta cycles, which sweep along spatial trajectories ahead of the animal, serve as a potential candidate. Previous research identified experience-independent, left-right-alternating theta sweeps as a mechanism for local spatial sampling. However, it remains unclear whether theta sweeps also facilitate trajectory evaluation toward distant, remembered goals. In rats performing goal-directed navigation in an open arena, we identified a distinct form of learning-dependent theta sequences that predicted upcoming goal-directed trajectories. These sequences coordinated with prefrontal cortical activity and were preferentially replayed during sharp-wave ripples. We described a circuit mechanism whereby egocentric goal-direction signals, combined with reduced feedback inhibition, generated goal-directed theta sweeps. Experience-dependent and goal-dependent theta sweeps thus provide a flexible mechanism for goal-directed navigation in open environments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.