Evidence map›Paper›PMID 42386939›Full record

ArticleCellular & molecular immunology2026

FAM234A acts as a switch between Th17 and Treg cell fate decisions that control inflammatory bowel disease.

Zhaoqi Zhang, Chenxu Zhao, Lingyun Sun, Tong Lei, Jinglin Xu, Guiying Wang, Yong Zhao

Abstract read
In one paragraph

Article in Cellular & molecular immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Zhaoqi Zhang *State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID 0000-0003-1568-0857
Chenxu Zhao *State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Lingyun Sun *State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Tong LeiState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Jinglin XuState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Guiying WangGeneral Surgery Department, The Second Hospital of Hebei Medical University, Shijiazhuang, China. wangguiying@hebmu.edu.cn.
Yong ZhaoState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. zhaoyong@suat-sz.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32300749National Natural Science Foundation of China (National Science Foundation of China) 32330037National Natural Science Foundation of China (National Science Foundation of China) 32500770
6 · The paper itself

Abstract

Appropriate T-cell functional polarization is critical for maintaining immune stability and immune tolerance. The role of Fam234a in the functional polarization of T cells is unknown. In a DSS-induced inflammatory bowel disease model in Rag2

Indexed as

Inflammatory Bowel DiseasesTh17 CellsT-Lymphocytes, RegulatoryAnimalsCell DifferentiationDNA-Binding ProteinsHumansMiceMice, Inbred C57BLMice, KnockoutUbiquitin-Specific ProteasesDNA-Binding ProteinsUbiquitin-Specific ProteasesDeubiquitinationFAM234AInflammatory bowel diseaseSynthetic biologyTh17Treg

Identifiers

PMID42386939
PMCPMC13424087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.