Evidence map›Paper›PMID 42386909›Full record

ArticleLeukemia2026

Single-cell DNA methylation analysis uncovers epigenetic pathways in the transformation of MDS to AML.

Alberto Bueno-Costa, Ignacio Campillo-Marcos, Marta Casado-Peláez, Karim Yassine, Aleix Noguera-Castells, Lurdes Zamora, Blanca Xicoy, Francesc Solé, Caterina Mata, Jane Park and 5 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Alberto Bueno-Costa *Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.
Ignacio Campillo-Marcos *Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.ORCID http://orcid.org/0000-0002-7657-7127
Marta Casado-Peláez *Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.
Karim YassineCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.
Aleix Noguera-CastellsCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.ORCID http://orcid.org/0000-0001-7436-6513
Lurdes ZamoraMyeloid Neoplasms Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.
Blanca XicoyMyeloid Neoplasms Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.ORCID http://orcid.org/0000-0002-0295-1307
Francesc SoléMyelodysplastic Syndromes (MDS) Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.ORCID http://orcid.org/0000-0002-3251-2161
Caterina MataSingle Cell Unit, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.
Jane ParkDivision of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Saravanan GanesanDivision of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Matteo Giovanni Della PortaIRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.ORCID http://orcid.org/0000-0002-6915-5970
Gerardo FerrerCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.ORCID http://orcid.org/0000-0002-4084-6815
Dan A LandauDivision of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-2346-9541
Manel EstellerCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain. mesteller@carrerasresearch.org.ORCID http://orcid.org/0000-0003-4490-6093

Funding

Charting the differentiation topology of SF3B1 mutated clonal hematopoiesis (CH) and myelodysplastic syndromes (MDS) via a multi-omics single-cell toolkitR01HL157387 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LANDAU, DAN · 2022 to 2025
$2.7M
Expanding the GoT toolkit to link single-cell clonal genotypes with protein, transcriptomic, epigenomic and spatial phenotypesR33CA267219 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LANDAU, DAN · 2022 to 2024
$1.2M
Ministry of Economy and Competitiveness | Agencia Estatal de Investigación (Spanish Agencia Estatal de Investigación) PID2024-159192OB-I00NCI NIH HHS R33 CA267219NHLBI NIH HHS R01 HL157387
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID42386909
PMCPMC13506333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.