Evidence map›Paper›PMID 42386839›Full record

ArticleScientific reports2026

Physiological shear flow enhances pinocytosis in human platelets.

Masataka Inoue, Kasumi Sagawa, Nobuo Watanabe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Masataka InoueSIT Research Laboratories, Shibaura Institute of Technology, Saitama, Japan. inoue.masataka.w2@shibaura-it.ac.jp.ORCID 0009-0006-5314-4122
Kasumi SagawaBiofluid Science and Engineering Laboratory, Department of Bio-Science and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology, Saitama, Japan.
Nobuo WatanabeBiofluid Science and Engineering Laboratory, Department of Bio-Science and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology, Saitama, Japan. nobuo@sic.shibaura-it.ac.jp.ORCID 0000-0001-9753-898X

Funding

Japan Society for the Promotion of Science 24KJ1977
6 · The paper itself

Abstract

Pinocytosis, the uptake of extracellular fluid, is an important yet poorly understood function of platelets. Although platelets are continuously exposed to shear flow in the circulation, the mechanism by which shear modulates pinocytosis in human platelets remains unclear. Here, we investigated the effects of physiological shear rate on platelet pinocytosis using a rotational viscometer combined with flow cytometric quantification using pHrodo dextran. Exposure to 500-1500 s

Indexed as

Blood PlateletsPinocytosisCalciumCalcium SignalingFlow CytometryHumansPlatelet ActivationP-SelectinStress, MechanicalCalciumP-SelectinCalcium signalingDrug deliveryFlow cytometryPinocytosisPlateletsShear flow

Identifiers

PMID42386839
PMCPMC13324158

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.