Evidence map›Paper›PMID 42386779›Full record

ArticleNature communications2026

Radical-omics reveals the hydrogen-abstraction pathway of isoprene oxidation.

Huan Song, Hongyang Cui, Huabin Dong, Ce Chen, Wenyu Wei, Yang Li, Qindan Zhu, Bo Tang, Chongqin Zhu, Xuefei Ma and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Huan Song *College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China.ORCID http://orcid.org/0000-0002-6884-9014
Hongyang Cui *Laboratory for Earth Surface Processes, College of Urban and Environmental Science, Peking University, Beijing, 100871, China.
Huabin Dong *College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China.
Ce Chen *College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China.
Wenyu WeiCollege of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China.
Yang LiCollege of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China.
Qindan ZhuDepartment of Earth, Atmospheric, and Planetary Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0003-2173-4014
Bo TangCollege of Chemistry, Beijing Normal University, Beijing, 100875, China.
Chongqin ZhuCollege of Chemistry, Beijing Normal University, Beijing, 100875, China.ORCID http://orcid.org/0000-0002-8316-1816
Xuefei MaCollege of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China.ORCID http://orcid.org/0000-0002-8200-4675
Zhaofeng TanCollege of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China.ORCID http://orcid.org/0000-0002-3808-1964
Shiyi ChenCollege of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China.
Yi WanLaboratory for Earth Surface Processes, College of Urban and Environmental Science, Peking University, Beijing, 100871, China. wany@urban.pku.edu.cn.ORCID http://orcid.org/0000-0003-1312-6254
Keding LuCollege of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China. k.lu@pku.edu.cn.ORCID http://orcid.org/0000-0001-9425-9520

Funding

China National Funds for Distinguished Young Scientists 22325601
6 · The paper itself

Abstract

Isoprene is the most abundant biogenic volatile organic compound (BVOC) and has far-reaching impacts on secondary organic aerosol (SOA) formation globally. Its atmospheric oxidation produces diverse isomeric radicals that drive subsequent chain propagation and mechanistic branching. However, high-throughput experimental characterization of these isomeric-resolved radicals remains unavailable, leaving critical gaps in the underlying molecular mechanisms. Here we establish a radical-omics approach for isomer-specific identification and detection of hundreds of radical species generated during VOCs oxidation. Applied to OH-initiated isoprene oxidation, this method enables experimental quantification of four OH-added allylic radicals and determination of their branching ratios. We further found hydrogen-abstraction to be an unexpectedly important pathway, contributing up to 8.78 ± 3.96% of total branching. Incorporating the updated mechanism into a global chemical transport model shows that this pathway contributes up to 13.5% of isoprene-derived low-volatility SOA over tropical rainforests. These results provide an experimental foundation for radical screening and targeted mechanistic validation, revealing hidden pathways in complex atmospheric conditions.

Identifiers

PMID42386779
PMCPMC13462587

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.