ArticleNPJ Parkinson's disease2026
Lewy pathology largely absent in prefrontal cortices of Parkinson's disease patients undergoing deep brain stimulation.
Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Parkinson's disease (PD) patients undergo deep brain stimulation (DBS) when other treatments are insufficient. Given the patients' advanced clinical stage, an advanced neuropathological stage is assumed. We examined Lewy pathology in prefrontal cortices (PFCs) of DBS recipients. Virtually no Lewy pathology was seen in PD biopsies. In contrast, postmortem PD PFC samples showed significantly greater Lewy pathology than controls. Thus, DBS patients may be less neuropathologically advanced in progression than previously thought.
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