Evidence map›Paper›PMID 42386749›Full record

ArticleNPJ Parkinson's disease2026

Multimodal neuroimaging elucidates the posterior-to-anterior gradient of nigrostriatal degeneration in Parkinson's disease.

Huamei Lin, Ying Zhang, Yixin Zhao, Yiman Wei, Benjamin F Combes, Martin T Henrich, Fanni F Geibl, Wolfgang H Oertel, Kuangyu Shi, Axel Rominger and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Huamei Lin *Department of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Ying Zhang *School of Medicine, Shanghai University, Shanghai, China.
Yixin Zhao *Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Yiman WeiUnited Imaging Healthcare Co., Ltd., Chengbei Road, Shanghai, China.
Benjamin F CombesInstitute for Biomedical Engineering, University, and ETH Zurich, Institute for Regenerative of Medicine, University of Zurich, Zurich, Switzerland.
Martin T HenrichDepartment of Psychiatry and Psychotherapy, Marburg University, Marburg, Germany.
Fanni F GeiblDepartment of Psychiatry and Psychotherapy, Marburg University, Marburg, Germany.
Wolfgang H OertelDepartment of Neurology, Marburg University, Marburg, Germany.
Kuangyu ShiDepartment of Nuclear Medicine, Inselspital, University of Bern, Bern, Switzerland.
Axel RomingerDepartment of Nuclear Medicine, Inselspital, University of Bern, Bern, Switzerland.
Ping WuDepartment of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Jingjie GeDepartment of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Jing WangDepartment of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Jiaying LuDepartment of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Zizhao JuDepartment of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Qian XuDepartment of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Huiwei ZhangDepartment of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Yunhao YangDepartment of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Zengping LinUnited Imaging Healthcare Co., Ltd., Chengbei Road, Shanghai, China.
Yang YangBeijing United Imaging Healthcare Co., Ltd., Beijing, China.
Yihui GuanDepartment of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Fengtao LiuDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Jian WangDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Jiehui JiangInstitute of Biomedical Engineering, School of Life Sciences, Shanghai University, Shanghai, China. jiangjiehui@shu.edu.cn.
Ruiqing NiInstitute for Biomedical Engineering, University, and ETH Zurich, Institute for Regenerative of Medicine, University of Zurich, Zurich, Switzerland. ruiqing.ni@unibe.ch.
Chuantao ZuoDepartment of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University, Shanghai, China. zuochuantao@fudan.edu.cn.

Funding

Brain Science and Brain-like Intelligence Technology-National Science and Technology Major Project 2022ZD0211600Shanghai Science and Technology Natural Science Foundation 25ZR1402042Shanghai Science and Technology Program Project 25TS1405000the National Nature Science Foundation of China No. 82394434, and 82272039
6 · The paper itself

Abstract

Parkinson's disease (PD) exhibits a characteristic posterior-to-anterior gradient of striatal dopamine loss, yet the underlying upstream mechanisms remain unclear. We combined in vivo ¹⁸F-FPCIT dopamine transporter (DaT) PET/MRI, quantitative susceptibility mapping, and diffusion MRI tractography in 48 PD patients and 10 healthy controls to test whether substantia nigra pars compacta (SNc) iron and microstructural disruption mediate posterior putaminal vulnerability. PD patients showed marked posterior putamen (pPut) DaT reduction (~60%) and elevated SNc iron. SNc iron negatively correlated with striatal DaT availability, and nigrostriatal pathways to the pPut exhibited higher axial diffusivity. Serial mediation analyses demonstrated that SNc iron indirectly impaired striatal DaT function via reduced SNc DaT binding. Putaminal DaT-SBR robustly discriminated PD from controls (AUC 0.93-0.96), exceeding caudate performance. Transgenic and α-synuclein preformed fibril mouse models provided qualitative anatomical support. These findings identify SNc iron-related degeneration as a key driver of posterior striatal vulnerability in PD.

Identifiers

PMID42386749
PMCPMC13686981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.