Evidence map›Paper›PMID 42386723›Full record

ArticleNature communications2026

Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis.

Munro Passmore, Xinyun Jian, Xinyi Zhao, Emmanuel L C de Los Santos, Douglas M Roberts, Józef R Lewandowski, Matthew Jenner, Lona M Alkhalaf, Gregory L Challis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Munro Passmore *Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Xinyun Jian *Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID 0000-0002-1276-4396
Xinyi ZhaoDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Emmanuel L C de Los SantosDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID 0000-0002-9496-9407
Douglas M RobertsDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Józef R LewandowskiDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID 0000-0001-6525-7083
Matthew JennerDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. M.Jenner@warwick.ac.uk.ORCID 0000-0003-2317-3011
Lona M AlkhalafDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. L.Alkhalaf.1@warwick.ac.uk.ORCID 0000-0001-7147-2775
Gregory L ChallisDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK. G.L.Challis@warwick.ac.uk.ORCID 0000-0001-5976-3545

Funding

RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/K002341/1RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/M01116X/1RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/M017982/1RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) UKRI723Royal Society WM130033
6 · The paper itself

Abstract

Polyketides and nonribosomal peptides are important natural product classes with wide-ranging medical and agricultural applications. The analogous enzymatic logic employed by bacterial modular polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) enables the assembly of hybrid products. One important group of polyketide-nonribosomal peptide hybrids is exemplified by the HDAC-targeting drug romidepsin. This group is assembled by combinatorial biosynthesis involving fusion of a conserved Zn

Indexed as

DepsipeptidesHistone Deacetylase InhibitorsBacterial ProteinsMultigene FamilyPeptide SynthasesPharmacophorePolyketidesPolyketide SynthasesBacterial ProteinsDepsipeptidesHistone Deacetylase Inhibitorsnon-ribosomal peptide synthasePeptide SynthasesPolyketidesPolyketide Synthasesromidepsin

Identifiers

PMID42386723
PMCPMC13324335

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.