The mechanism of 45S5 bioactive glass-mediated, cell-type-specific death of bone tumor cells.

Joerg Fellenberg, Sarina Losch, Marcela Arango-Ospina, Fabian Westhauser, Burkhard Lehner, Aldo R Boccaccini

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Article in Cell death discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Joerg FellenbergResearch Centre for Molecular and Regenerative Orthopaedics, Department of Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany. Joerg.Fellenberg@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-6187-6474

Sarina LoschResearch Centre for Molecular and Regenerative Orthopaedics, Department of Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany.

Marcela Arango-OspinaInstitute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Erlangen, Germany.

Fabian WesthauserDepartment of Orthopaedics, University of Regensburg, Bad Abbach, Germany.

Burkhard LehnerResearch Centre for Molecular and Regenerative Orthopaedics, Department of Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany.

Aldo R BoccacciniInstitute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Erlangen, Germany.

Funding

Deutsche Krebshilfe (German Cancer Aid) 70115225

6 · The paper itself

Abstract

Despite advances in treatment modalities, current bone tumor therapies still face significant challenges, including severe side effects of conventional approaches, poor survival rates and high rates of tumor recurrence. We previously identified a strong cytotoxic effect of 45S5-bioactive glass (BG) particles on bone tumor cells, indicating possible therapeutic properties of these materials. In order to identify the mechanisms that trigger tumor cell death, we investigated the impact of 45S5-BG on bone tumor cells compared to non-neoplastic cells. Regardless of cell type, BG treatment induced oxidative stress and increased ROS production. Fluorescently labeled SiO

Identifiers

PMID42386707

DOI10.1038/s41420-026-03211-x

PMCPMC13324152

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