SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2026
Respiratory support in paediatric patients with bronchiolitis: a systematic review and meta-analysis.
Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Process mapping: finding new routes to guideline adherence.Pediatric research · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent evidence suggests that high-flow nasal cannula (HFNC) may confer better clinical outcomes compared with other respiratory support modalities in paediatric patients with bronchiolitis.
methodsWe performed a literature search up to 21 January 2024 on PubMed, Scopus, Cochrane Library, Embase, Cumulative Index to Nursing and Allied Health Literature, World Health Organization International Clinical Trials Registry Platform and Clinicaltrials.gov. Randomised controlled studies including paediatric patients aged ≤24 months with bronchiolitis comparing the use of HFNC
results18 studies with 4094 patients were included. HFNC did not reduce the need for mechanical ventilation compared to LFNC (risk ratio 0.69, 95% CI 0.33-1.44; p=0.32) or CPAP (risk ratio 0.90, 95% CI 0.65-1.24; p=0.52). HFNC resulted in less treatment failure compared to LFNC (risk ratio 0.44, 95% CI 0.23-0.87; p=0.02), whereas there was no difference compared to CPAP (risk ratio 1.28, 95% CI 0.90-1.80; p=0.17). HFNC was associated with significant reduction in length of paediatric intensive care unit (PICU) stay compared to LFNC (mean difference (MD) -0.40 95% CI -0.78- -0.02; p=0.04), but not compared to CPAP (MD -0.24, 95% CI -0.91-0.43; p=0.47).
interpretationHFNC significantly reduced treatment failure, length of PICU stay and total oxygen therapy duration compared to LFNC. No differences between HFNC and CPAP in primary and secondary outcomes. HFNC could be considered as initial treatment modality in paediatric patients with bronchiolitis, especially in patients requiring escalation of treatment from LFNC.
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