ReviewEuropean respiratory review : an official journal of the European Respiratory Society2026
East Asia as a sentinel: risk-stratified corticosteroid therapy for paediatric macrolide-resistant
Review in European respiratory review : an official journal of the European Respiratory Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
background
methodsThis structured narrative review was conducted using PubMed and Embase databases to identify relevant studies published between 2000 and 2025. Clinical studies, biomarker analyses and regional guidelines, particularly from East Asia, were reviewed to examine the indications, timing and risk-stratified use of systemic corticosteroids in refractory and severe
resultsAvailable evidence suggests that management of MRMP often involves both second-line antimicrobial therapy and consideration of adjunctive immunomodulation. Among available biomarkers, lactate dehydrogenase (LDH) has been most frequently reported in association with refractory disease. Elevated LDH levels (commonly around 400 IU·L
conclusionCorticosteroids may represent a potential adjunctive strategy rather than a last-resort intervention in selected patients. A risk-stratified approach integrating clinical severity, radiologic progression and biomarker profiles may help guide individualised treatment decisions, although the overall evidence remains heterogeneous and further studies are needed.
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