Evidence map›Paper›PMID 42386305›Full record

ArticleBMJ open2026

Severe Mental Illness Longitudinal Evaluation (SMILE): protocol for establishing a cohort and bioresource for UK-based patients with psychosis.

Anthony Quinn, Thomas Johnson, Julie Bieles, Lesley Booth, Robert A McCutcheon, John Bradley, Nathalie Kingston, Gerome Breen, Amelia Harshfield, Graham K Murray and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Anthony QuinnDepartment of Psychiatry, University of Oxford, Oxford, Oxfordshire, UK anthony.quinn@psych.ox.ac.uk.ORCID http://orcid.org/0000-0003-4245-1996
Thomas JohnsonDepartment of Psychiatry, University of Oxford, Oxford, Oxfordshire, UK.
Julie BielesDepartment of Psychiatry, University of Oxford, Oxford, Oxfordshire, UK.
Lesley BoothDepartment of Psychiatry, University of Oxford, Oxford, Oxfordshire, UK.ORCID http://orcid.org/0009-0004-6607-9281
Robert A McCutcheonDepartment of Psychiatry, University of Oxford, Oxford, Oxfordshire, UK.
John BradleyNIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
Nathalie KingstonNIHR BioResource, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK.
Gerome BreenSocial, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Amelia HarshfieldDepartment of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK.
Graham K MurrayDepartment of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK.ORCID http://orcid.org/0000-0001-8296-1742
James T R WaltersCentre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.
Benjamin I PerryInstitute for Mental Health, University of Birmingham, Birmingham, UK.
Mohammad Zia Ul Haq KatshuInstitute of Mental Health, University of Nottingham, Nottingham, Nottinghamshire, UK.
Kimberley KendallCentre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.
Rachel UpthegroveDepartment of Psychiatry, University of Oxford, Oxford, Oxfordshire, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPsychotic disorders account for significant morbidity and healthcare costs and yet their pathophysiology remains poorly understood. The National Institute for Health and Care Research (NIHR) Severe Mental Illness Longitudinal Evaluation (SMILE) BioResource is a collaborative project that aims to collect clinical data and biological samples from people with psychosis for long-term storage, future projects and recontact for targeted trials. METHODS AND ANALYSIS: The NIHR SMILE BioResource cohort will initially include up to 2000 UK-based patients with a recorded diagnosis of psychosis. Clinical symptoms will be captured using self-report and clinician ratings. Biosamples will enable genotyping and wider omics as further funding allows. Study data will be analysed to facilitate development of discovery science for underlying mechanisms of psychotic disorders and recall of participants for targeted interventional studies. ETHICS AND DISSEMINATION: This study is sponsored by the University of Oxford and received full ethical approval from Wales REC 2. SMILE BioResource biosamples and data will be stored long-term by the NIHR BioResource. Researchers who are interested in applying to use these biosamples and data, and/or recontacting SMILE participants can find further information on the website of the NIHR BioResource.

Indexed as

Biological Specimen BanksPsychotic DisordersHumansLongitudinal StudiesResearch DesignUnited KingdomAdult psychiatryGenomic MedicineMENTAL HEALTHSchizophrenia & psychotic disorders

Identifiers

PMID42386305
PMCPMC13331059

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.