Evidence map›Paper›PMID 42386294›Full record

Observational studyBMJ open2026

Exercise performance in patients with heart failure and impaired iron transport: a single-centre retrospective study.

Jeness Campodonico, Alice Bonomi, Beatrice Pezzuto, Carlo Vignati, Massimo Mapelli, Beatrice Lorenzon, Alessandro Acquistapace, Alp Ayvali, Irene Mattavelli, Elisabetta Salvioni and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jeness CampodonicoCentro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.
Alice BonomiCentro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.
Beatrice PezzutoCentro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.
Carlo VignatiCentro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.
Massimo MapelliCentro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.
Beatrice LorenzonDepartment of Clinical Science and Community Health, Cardiovascular Section, University of Milan, Milan, Italy.
Alessandro AcquistapaceDepartment of Clinical Science and Community Health, Cardiovascular Section, University of Milan, Milan, Italy.
Alp AyvaliDepartment of Clinical Science and Community Health, Cardiovascular Section, University of Milan, Milan, Italy.
Irene MattavelliCentro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.
Elisabetta SalvioniCentro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.
Piergiuseppe AgostoniCentro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy Piergiuseppe.Agostoni@ccfm.it.ORCID http://orcid.org/0000-0002-8345-6382

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIron deficiency (ID) is frequent in heart failure (HF). Among patients with HF and ID, those with impaired iron transport (IIT) (transferrin saturation (TSAT) <20%) have the worst ID phenotype. In HF, exercise limitation is mainly related to abnormality in oxygen delivery (VO

designObservational study.

settingRetrospective study.

participantsWe analysed 1043 consecutive hospitalised patients with HF (66±14 years, 49.8% females) who underwent cardiopulmonary exercise test (CPET). OUTCOME MEASURES: Associations between CPET parameters and TSAT were explored using general linear models adjusted for potential confounders (haemoglobin, left ventricle ejection fraction, age, gender, C reactive protein, serum creatinine).

resultsWe observed that: (a) 413 patients with HF and IIT had worse functional capacity compared with non-IIT cases: peak VO

conclusionsHigh VE/VCO

Indexed as

Anemia, Iron-DeficiencyExercise ToleranceHeart FailureIronAgedExercise TestFemaleHumansMaleMiddle AgedOxygen ConsumptionRetrospective StudiesIronExercise TestHeart failureOther metabolic, e.g. iron, porphyria

Identifiers

PMID42386294
PMCPMC13331156

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.