ArticleLuminescence : the journal of biological and chemical luminescence2026
A Novel Green Spectrofluorimetric Approach for Memantine Quantification With Mechanistic Elucidation Through Quantum Mechanical Modeling and Green Analytical Chemistry Evaluation.
Article in Luminescence : the journal of biological and chemical luminescence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A novel, sustainable spectrofluorimetric method was developed for memantine determination using erythrosin B as a fluorescent probe, addressing critical analytical gaps in pharmaceutical quality control and environmental monitoring. The method exploits static fluorescence quenching through ground-state complex formation between protonated memantine and anionic erythrosin B. Initially, UV-Vis absorption spectroscopy revealed a significant hypochromic effect accompanied by a hypsochromic shift of 5 nm, with the absorption maximum shifting from 527 to 522 nm upon complex formation, while fluorescence studies demonstrated concentration-dependent quenching at 527 nm excitation and 553 nm emission wavelengths. Subsequently, temperature-dependent Stern-Volmer analysis yielded quenching constants decreasing from 6.22 × 10
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