Evidence map›Paper›PMID 42385717›Full record

ArticleAmerican journal of human genetics2026

Genome-wide association study and predictors of neonatal blood cell traits in Hispanic newborns.

Yunqi Li, Benjamin Alonzo, Zixuan E Zhang, Jalen Langie, Swe Swe Myint, Michaela Ince, Rong Lu, Charleston W K Chiang, Steven Gazal, Nicholas Mancuso and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yunqi LiCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA.
Benjamin AlonzoCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA.
Zixuan E ZhangCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jalen LangieCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA.
Swe Swe MyintCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA.
Michaela InceCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA.
Rong LuUSC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA; Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Charleston W K ChiangCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.
Steven GazalCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA.
Nicholas MancusoCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA.
Linda KachuriDepartment of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Adam J de SmithCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA; Department of Pediatrics, City of Hope, Duarte, CA 91010, USA. Electronic address: adesmith@coh.org.

Funding

Understanding the Increased Risk of Childhood Acute Lymphoblastic Leukemia in LatinosR01CA262263 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Adam De Smith · 2022 to 2026
$3.4M
NCI NIH HHS R01 CA262263
6 · The paper itself

Abstract

The role of heritable genetic variation in hematologic traits in adults is well established, yet the genetic architecture of neonatal blood cell traits is unknown. Leveraging flow cytometry profiling in cord blood samples from 382 Hispanic newborns, we conducted genome-wide association studies (GWASs) of 24 blood cell phenotypes to assess the impact of genetic and birth-related characteristics. We identified six genome-wide significant loci, including a signal at chromosome 2p11.2 spanning CD8A and CD8B that was associated with CD4

Indexed as

Blood CellsGenome-Wide Association StudyHispanic or LatinoQuantitative Trait LociCD8-Positive T-LymphocytesFemaleFetal BloodGene FrequencyHumansInfant, NewbornKiller Cells, NaturalMalePhenotypePolymorphism, Single Nucleotideblood cell traitscord bloodgenome-wide association studyGWASHispanicimmune cell traitsLatinomode of deliveryneonatalnewborns

Identifiers

PMID42385717
PMCPMC13336320

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.