Evidence map›Paper›PMID 42385715›Full record

ArticleCell reports2026

Dysregulated calcium signaling underlies hyposalivation and microbial dysbiosis in Down syndrome.

Ga-Yeon Son, Guilherme H S Bomfim, Fangxi Xu, Scott C Thomas, Kristen Rosenberg, Tommy Kim, Eleni Rice, Enkhnaran Budjav, Rebecca Jones, Yin-Hu Wang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ga-Yeon SonDepartment Molecular Pathobiology, NYU Dentistry, New York, NY, USA.
Guilherme H S BomfimDepartment Molecular Pathobiology, NYU Dentistry, New York, NY, USA.
Fangxi XuDepartment Molecular Pathobiology, NYU Dentistry, New York, NY, USA.
Scott C ThomasDepartment Molecular Pathobiology, NYU Dentistry, New York, NY, USA.
Kristen RosenbergDepartment Molecular Pathobiology, NYU Dentistry, New York, NY, USA.
Tommy KimDepartment Molecular Pathobiology, NYU Dentistry, New York, NY, USA.
Eleni RiceDepartment Molecular Pathobiology, NYU Dentistry, New York, NY, USA.
Enkhnaran BudjavDepartment Biology, New York University, New York, NY, USA.
Rebecca JonesDepartment of Biochemistry and Molecular Pharmacology, Department of Radiation Oncology, NYU Grossman School of Medicine, New York, NY, USA.
Yin-Hu WangDepartment of Pathology, NYU Grossman School of Medicine, New York, NY, USA.
Erna MitaishviliDepartment Molecular Pathobiology, NYU Dentistry, New York, NY, USA.
Stefan FeskeDepartment of Pathology, NYU Grossman School of Medicine, New York, NY, USA.
Drew R JonesDepartment of Biochemistry and Molecular Pharmacology, Department of Radiation Oncology, NYU Grossman School of Medicine, New York, NY, USA.
Edwin Rosado-OlivieriDepartment Molecular Pathobiology, NYU Dentistry, New York, NY, USA.
Beverly A RothermelDepartments of Internal Medicine and Molecular Biology, UT Southwestern Medical Center, Dallas, TX, USA.
Deepak SaxenaDepartment Molecular Pathobiology, NYU Dentistry, New York, NY, USA.
Rodrigo S LacruzDepartment Molecular Pathobiology, NYU Dentistry, New York, NY, USA. Electronic address: rsl10@nyu.edu.

Funding

Ca2+ signaling via SOCE in the pathogenesis of Sjögren’s syndromeR01DE027981 · NIDCR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN, LACRUZ, RODRIGO S. · 2019 to 2023
$2.7M
Molecular mechanisms of oral deficiencies in Down syndromeR01DE032846 · NIDCR · NEW YORK UNIVERSITY · PI Rodrigo S. Lacruz · 2023 to 2026
$2.6M
Elevated mitochondrial fusion and function in Down syndrome - Revision - 2R01HD101006 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI ROTHERMEL, BEVERLY A · 2019 to 2022
$2.2M
CRISPR interference to identify HSA21 genes reducing neurogenesisR21HD118402 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI MUNSHI, NIKHIL VILAS, ROTHERMEL, BEVERLY A · 2025 to 2025
$451k
NICHD NIH HHS R01 HD101006NICHD NIH HHS R21 HD118402NIDCR NIH HHS R01 DE027981NIDCR NIH HHS R01 DE032846
6 · The paper itself

Abstract

Individuals with Down syndrome (DS) produce less saliva for unknown reasons resulting in chronic periodontal disease with systemic detrimental effects. Using the (Dp(16)1Yey) mouse model of DS we define the molecular mechanisms of hyposalivation and potential links to periodontal disease. We show that Dp(16)1Yey mice produce less saliva and have a higher immune burden in the salivary glands. We demonstrate that store operated calcium entry (SOCE), required for saliva secretion, is deficient in the salivary glands of Dp(16)1Yey mice. SOCE is also reduced in iPSCs from an individual with DS. We show that the oral and gut microbiomes of Dp(16)1Yey mice have abundant succinate-associated microbes and high succinate levels in the serum. We highlight associations between altered Ca

Indexed as

Calcium SignalingDown SyndromeDysbiosisXerostomiaAnimalsCalciumHumansMicePilocarpineSalivary GlandsSalivationSuccinic AcidCalciumPilocarpineSuccinic Acidcalcium signalingcholinergic agonistCP: cell biologyCP: microbiologyDown syndromedysbiosishyposalivationmetabolismperiodontal diseasesalivary glandsSjogren's diseasesuccinate

Identifiers

PMID42385715
PMCPMC13545736

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.