ArticleDevelopmental cell2026
AXIN1 and AXIN2 regulate the WNT-signaling landscape to promote distinct mesoderm programs.
Article in Developmental cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Regulation of mRNA poly(A) tail length governs mammalian body plan formation in gastruloids.Nature communications · 2026Article
- Article
- YAP1 and QSER1 are key modulators of embryonic signaling pathways in the mammalian epiblast.EMBO reports · 2026Article
- YAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast.bioRxiv : the preprint server for biology · 2025Article
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9 authors.
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Abstract
How distinct lineage identities are specified from pluripotent epiblast cells during gastrulation is a longstanding open question. By investigating AXIN, a negative regulator of the WNT/β-catenin pathway, we have uncovered previously unrecognized roles for WNT signaling in the specification of distinct mesoderm identities. Using complementary approaches, including a detailed analysis of Axin1;Axin2 mutant mouse embryos involving single-cell and single-embryo transcriptomics and in vitro pluripotent stem cell differentiation assays, our data revealed two critical layers of regulation. First, WNT initiates differentiation of primitive streak cells into mesoderm progenitors. Next, WNT amplifies and cooperates with bone morphogenetic protein (BMP)/pSMAD1/5/9 or NODAL/pSMAD2/3 to propel differentiating mesoderm progenitors into either posterior or anterior streak identities, respectively. We propose that Axin1 and Axin2 function to prevent precocious differentiation of pluripotent epiblast cells into mesoderm through the spatiotemporal regulation of WNT-signaling levels.
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