Evidence map›Paper›PMID 42385698›Full record

ArticleNeuron2026

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Prashanthi Ravichandran, Svitlana V Bach, Robert A Phillips, Madeline R Valentine, Nicholas J Eagles, Yufeng Du, Ishbel Del Rosario, Haya A AlGrain, Sarah E Maguire, Ryan A Miller and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Prashanthi RavichandranDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21218, USA.
Svitlana V BachLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA.
Robert A PhillipsLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA.
Madeline R ValentineLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA.
Nicholas J EaglesLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA.
Yufeng DuLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA.
Ishbel Del RosarioLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA.
Haya A AlGrainLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA.
Sarah E MaguireLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA.
Ryan A MillerLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA.
Heena R DivechaLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA; Neuroscience Graduate Training Program, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Madhavi TippaniLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA.
Kelsey D MontgomeryLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA.
Joel E KleinmanLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Shizhong HanLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA; Department of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Stephanie C PageLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Thomas M HydeLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Leonardo Collado-TorresLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA; Center for Computational Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
Alexis BattleDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21218, USA; Department of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, USA; Malone Center for Engineering in Healthcare, Johns Hopkins University, Baltimore, MD 21218, USA.
Keri MartinowichLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Johns Hopkins Kavli Neuroscience Discovery Institute, Baltimore, MD 21205, USA.
Stephanie C HicksDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21218, USA; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA; Center for Computational Biology, Johns Hopkins University, Baltimore, MD 21218, USA; Malone Center for Engineering in Healthcare, Johns Hopkins University, Baltimore, MD 21218, USA; Johns Hopkins Kavli Neuroscience Discovery Institute, Baltimore, MD 21205, USA. Electronic address: shicks19@jhu.edu.
Kristen R MaynardLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address: kristen.maynard@libd.org.

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ALLISON L AGWU · 2012 to 2026
$67.0M
Registration of spatial gene expression in key nodes of reward-related circuitry in the human brainR01DA053581 · NIDA · LIEBER INSTITUTE, INC. · PI MARTINOWICH, KERI · 2021 to 2025
$3.7M
Modeling the dynamicimpact of rare and common genetic variation on gene expression anddiseaseR35GM139580 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BATTLE, ALEXIS · 2021 to 2025
$3.1M
MoFlo to MoFlo XDP Upgrade for BSL3 SortingS10OD016315 · OD · JOHNS HOPKINS UNIVERSITY · PI MARGOLICK, JOSEPH B. · 2013 to 2013
$233k
Identifying a functional role for transcriptionally distinct, BLA-activated LS ensembles in social behaviorsF32MH139150 · NIMH · LIEBER INSTITUTE, INC. · PI Robert Phillips · 2024 to 2026
$161k
NIAID NIH HHS P30 AI094189NIDA NIH HHS R01 DA053581NIGMS NIH HHS R35 GM139580NIH HHS S10 OD016315NIMH NIH HHS F32 MH139150
6 · The paper itself

Abstract

The nucleus accumbens (NAc) is a key component of the mesolimbic dopamine system that is implicated in several neuropsychiatric disorders. The NAc contains transcriptomically distinct medium spiny neuron (MSN) subtypes, but their spatial organization remains unclear. We generated a spatiomolecular atlas of the human NAc by integrating paired single-cell and spatial transcriptomics of postmortem NAc tissue. We identified transcriptionally unique cell populations and spatial domains (SpDs), including D1 islands composed of discrete MSN subtypes enriched for dopamine receptor D1 (DRD1) and OPRM1. We demonstrated continuous spatial gene expression gradients across the NAc and evolutionary conservation of spatial features. We also identified SpDs associated with risk for psychiatric and addiction-related traits and spatially mapped risk-associated ligand-receptor interactions. Finally, we predicted enrichment of drug-responsive transcriptional programs in both SpDs and cell types. Collectively, we provide a spatiomolecular framework for understanding the relevance of the human NAc in neuropsychiatric diseases.

Indexed as

D1 islandsmedium spiny neuronnucleus accumbenspostmortem human brainsingle-nucleus RNA sequencingspatially resolved transcriptomics

Identifiers

PMID42385698
PMCPMC13378871

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.