Evidence map›Paper›PMID 42385388›Full record

ArticleRedox biology2026

Apurinic/apyrimidinic endonuclease 1 prevents oxidative DNA damage in intestinal epithelial cells induced by genotoxic Escherichia coli NC101.

Lindsay D Butcher, Gerco den Hartog, Amber L Ablack, Mason Matsubara, Leonid M Rovner, David Rios-Covian, Taren Thron, Sarkis K Mazmanian, Jailal N G Ablack, Thaddeus Stappenbeck and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Lindsay D ButcherDivision of Gastroenterology, Deparment of Medicine, University of California, San Diego, La Jolla, CA, 92093-0063, USA.
Gerco den HartogDivision of Gastroenterology, Deparment of Medicine, University of California, San Diego, La Jolla, CA, 92093-0063, USA.
Amber L AblackDivision of Gastroenterology, Deparment of Medicine, University of California, San Diego, La Jolla, CA, 92093-0063, USA.
Mason MatsubaraDivision of Gastroenterology, Deparment of Medicine, University of California, San Diego, La Jolla, CA, 92093-0063, USA.
Leonid M RovnerDivision of Gastroenterology, Deparment of Medicine, University of California, San Diego, La Jolla, CA, 92093-0063, USA.
David Rios-CovianThe Chiba University-UCSD Center for Mucosal Immunology, Allergy and Vaccine Development, the Division of Comparative Pathology and Medicine, Center of Veterinary Sciences and Comparative Medicine, Department of Pathology, University of California San Diego, La Jolla, CA, 92093-0063, USA.
Taren ThronDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Sarkis K MazmanianDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Jailal N G AblackDivision of Rheumatology, University of California San Diego, La Jolla, CA, 92093, USA.
Thaddeus StappenbeckDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Lars EckmannDivision of Gastroenterology, Deparment of Medicine, University of California, San Diego, La Jolla, CA, 92093-0063, USA.
Tadahide IzumiDivision of Gastroenterology and Hepatology, Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536, USA.
Alina TirlaDepartment of Chemistry, Yale University, New Haven, CT, USA.
Kevin M WernkeDepartment of Chemistry, Yale University, New Haven, CT, USA.
Seth B HerzonDepartment of Chemistry, Yale University, New Haven, CT, USA.
Michael W DoughertyDepartment of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Christian JobinDepartment of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Hiroshi KiyonoThe Chiba University-UCSD Center for Mucosal Immunology, Allergy and Vaccine Development, the Division of Comparative Pathology and Medicine, Center of Veterinary Sciences and Comparative Medicine, Department of Pathology, University of California San Diego, La Jolla, CA, 92093-0063, USA.
Peter B ErnstThe Chiba University-UCSD Center for Mucosal Immunology, Allergy and Vaccine Development, the Division of Comparative Pathology and Medicine, Center of Veterinary Sciences and Comparative Medicine, Department of Pathology, University of California San Diego, La Jolla, CA, 92093-0063, USA. Electronic address: pernst@ucsd.edu.
Sheila E CroweDivision of Gastroenterology, Deparment of Medicine, University of California, San Diego, La Jolla, CA, 92093-0063, USA.

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
UCD Mutant Mouse Regional Resource CenterU42OD012210 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2012 to 2026
$29.2M
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Training Grant in GastroenterologyT32DK007202 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 1985 to 2022
$7.7M
Structural and functional studies of colibactinR01CA215553 · NCI · YALE UNIVERSITY · PI Seth B. Herzon, Christian Jobin · 2018 to 2026
$5.5M
The Role of the Adenosine Receptor in Th Cell Development and FunctionR01AI079145 · NIAID · UNIVERSITY OF VIRGINIA · PI ERNST, PETER B. · 2010 to 2022
$4.7M
NCI NIH HHS P30 CA023100NCI NIH HHS R01 CA215553NIAID NIH HHS R01 AI079145NIDDK NIH HHS P30 DK120515NIDDK NIH HHS T32 DK007202NIH HHS U42 OD012210NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

backgroundApurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional protein that regulates host responses to oxidative stress. We investigated its role in controlling DNA damage following infection with a genotoxic intestinal microbe.

methodsMice rendered hypomorphic for APE1 were crossed with tamoxifen (TMX)-inducible or constitutive Vil1ACre mice to yield intestinal epithelial cell-targeted knockout mice (Apex1

resultsAPE1 expression was markedly diminished in enterocytes of Apex1

conclusionsAPE1 protects epithelial cells by inhibiting the accumulation of ROS and oxidative DNA damage induced by intestinal bacteria, including the colibactin produced by E. coli NC101.

Indexed as

DNA-(Apurinic or Apyrimidinic Site) LyaseDNA DamageEpithelial CellsEscherichia coliEscherichia coli InfectionsIntestinal MucosaOxidative StressAnimalsCell LineHumansMiceMice, KnockoutPeptidesPolyketidesReactive Oxygen SpeciesApex1 protein, mousecolibactinDNA-(Apurinic or Apyrimidinic Site) LyasePeptidesPolyketidesReactive Oxygen SpeciesAP endonuclease 1Colorectal cancerDNA damageGenotoxinOxidative stress

Identifiers

PMID42385388
PMCPMC13352041

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.