Observational studyRevista da Associacao Medica Brasileira (1992)2026
Assessment of vital organ oxygenation by near-infrared spectroscopy in pharmacologic closure therapy for patent ductus arteriosus in preterm neonates.
Observational study in Revista da Associacao Medica Brasileira (1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHemodynamically significant patent ductus arteriosus is a frequent problem in preterm neonates and may impair systemic and organ-specific oxygenation. Near-infrared spectroscopy provides a non-invasive tool to evaluate regional tissue oxygenation. The aim of this study was to investigate the effects of pharmacological closure therapy on cerebral, renal, and mesenteric tissue oxygenation in preterm neonates diagnosed with hemodynamically significant patent ductus arteriosus.
methodsThis prospective observational study was conducted in a tertiary neonatal intensive care unit between September 2021 and November 2024. Twenty-four preterm infants (24-34 weeks' gestational age) with hemodynamically significant patent ductus arteriosus confirmed by transthoracic echocardiography were enrolled. Paracetamol treatment was given in cases where ibuprofen was contraindicated. Patients who underwent medical patent ductus arteriosus closure were divided into two groups: ibuprofen and paracetamol groups. Specific regional tissue oxygen saturation and fractional tissue oxygen extraction in three regions were monitored continuously using near-infrared spectroscopy for 72 h before and after medical treatment. Echocardiographic and hemodynamic parameters were recorded.
resultsWhile patent ductus arteriosus closure was achieved in 46% of cases with medical treatment, a significant reduction in patent ductus arteriosus diameter was achieved in 29% of cases. Ibuprofen was superior to paracetamol in reducing patent ductus arteriosus diameter. Mesenteric regional tissue oxygen saturation also improved significantly at 24-48 h in the ibuprofen group (p=0.01), while cerebral and renal oxygenation remained unchanged (p>0.05).
conclusionOur findings revealed that ibuprofen therapy improved hemodynamic stability and mesenteric oxygenation in preterm neonates with hemodynamically significant patent ductus arteriosus. Although we showed in our study that there was no significant change in cerebral and renal oxygenation of hemodynamically significant patent ductus arteriosus with ibuprofen treatment, more comprehensive studies showing the changes with near-infrared spectroscopy are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.