ArticleActa cirurgica brasileira2026
Astaxanthin alleviates autophagy, inflammation, and oxidative stress in ventilator-associated lung injury rats by inhibiting MAPK/ERK1/2 pathway.
Article in Acta cirurgica brasileira, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeImproper use of mechanical ventilation may result in ventilator-induced lung injury (VILI). This work seeks to explore the preventive impact of astaxanthin on VILI.
methodsIn this study, we established the VILI rat and drug intervention model, then evaluated lung tissue damage by observing the appearance and hematoxylin-eosin staining. Oxidative stress was evaluated by determining the levels of myeloperoxidase, catalase, and malondialdehyde.
resultsOur data showed that, compared with the control group, mechanical ventilation increased the mRNA and protein expression levels of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, LC3II/I, and Beclin1, as well as the phosphorylation level of ERK1/2 in the lung tissues of VILI rats (p < 0.0001), while the expression level of P62 protein decreased (p < 0.0001). After pretreatment with astaxanthin, autophagy and inflammatory response were significantly reduced. The phosphorylation of ERK1/2 was also inhibited. Notably, these effects were reversed after using the p-ERK agonist Ro67-7476.
conclusionAstaxanthin can inhibit autophagy levels and suppress inflammation and oxidative stress in mechanically ventilated rat lung tissue through inhibiting the MAPK/ERK signaling pathway, thus alleviating lung tissue injury. Therefore, astaxanthin may represent a promising preventive strategy for VILI.
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