Evidence map›Paper›PMID 42384950›Full record

Trial reportRheumatology (Oxford, England)2026

Personalized, physiotherapist-guided exercise programs in JIA: home-based vs. immersive virtual reality (JiaFitXR).

Nilay Arman, Asya Albayrak, İrem Dönmez, Yusuf Açıkgöz, Asena Yekdaneh, Figen Çakmak, Betül Sözeri, Nuray Aktay Ayaz

Registry-linked trialAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Rheumatology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06176846 (Effect of Immersive Virtual Reality Exergaming Program on Physical Fitness, Functional Capacity and Physical Activity In Adolescents Diagnosed With Juvenile Idiopathic Arthritis), which is not on this map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06176846 naunknown statusnot on this map

Effect of Immersive Virtual Reality Exergaming Program on Physical Fitness, Functional Capacity and Physical Activity In Adolescents Diagnosed With Juvenile Idiopathic Arthritis: A Randomized Controlled Study

TypeinterventionalSponsorIstanbul University - CerrahpasaRan2023 to 2024Enrolled40ConditionsJuvenile Idiopathic ArthritisArmsImmersive Virtual Reality Exergaming Program, Home-Based Exercise Program
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nilay ArmanDepartment of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Istanbul University-Cerrahpasa, Istanbul, Türkiye.ORCID 0000-0002-0830-6595
Asya AlbayrakInstitute of Graduate Studies, Physiotherapy and Rehabilitation Doctorate Program, Istanbul University-Cerrahpasa, Istanbul, Türkiye.ORCID 0000-0003-4648-9174
İrem DönmezInstitute of Graduate Studies, Physiotherapy and Rehabilitation Master of Science Program, Istanbul University-Cerrahpasa, Istanbul, Türkiye.ORCID 0009-0003-7438-8829
Yusuf AçıkgözInstitute of Graduate Studies, Physiotherapy and Rehabilitation Master of Science Program, Istanbul University-Cerrahpasa, Istanbul, Türkiye.ORCID 0009-0008-5784-7735
Asena YekdanehInstitute of Graduate Studies, Physiotherapy and Rehabilitation Doctorate Program, Istanbul University-Cerrahpasa, Istanbul, Türkiye.ORCID 0000-0003-0764-205X
Figen ÇakmakDepartment of Pediatric Rheumatology, Basaksehir Cam and Sakura Hospital, Istanbul, Türkiye.ORCID 0000-0002-1667-2480
Betül SözeriDepartment of Pediatric Rheumatology, Umraniye Training and Research Hospital, Istanbul, Türkiye.ORCID 0000-0002-5079-5644
Nuray Aktay AyazDepartment of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.ORCID 0000-0003-3594-7387

Funding

Global Health Through Competitive Grant Program 88560557
6 · The paper itself

Abstract

objectiveTo compare the effects of two physiotherapist-guided, personalized, stepwise-adapted exercise interventions-a home-based program (HomeEX) and an immersive virtual reality (IVR) exergaming program (JiaFitXR)-on physical fitness, functional capacity and physical activity in adolescents with Juvenile Idiopathic Arthritis (JIA).

methodsThis randomized controlled trial included 50 adolescents aged 13-18 years with JIA, randomly assigned (1:1) to HomeEX or JiaFitXR. Both programs targeted balance, strength, endurance and agility, delivered twice weekly for 8 weeks under physiotherapist supervision. Functional capacity (6-Min Walk Test, Sit-to-Stand, Step-Up/Step-Down tests) and physical fitness (FitnessGram components, muscle strength, EMG activation, grip force) were assessed pre- and post-intervention by blinded physiotherapists. Analyses were performed using paired and independent t-tests and repeated-measures ANOVA, following the intention-to-treat principle.

resultsBoth physiotherapist-guided interventions significantly improved physical fitness, functional capacity and daily activity (P < 0.05). Greater gains in 1-Min Sit-to-Stand, Step-Up and Step-Down tests, as well as in lower-extremity endurance and neuromuscular activation, were observed in the JiaFitXR group (P < 0.05). The HomeEX group showed superior improvements in flexibility and upper-extremity strength (P < 0.05). Step counts increased similarly in both the groups, while perceived exertion remained stable throughout the program.

conclusionBoth physiotherapist-guided exercise approaches effectively enhanced physical and functional outcomes in adolescents with JIA. The IVR-based intervention provided additional benefits in lower-extremity endurance and engagement, supporting its potential as an innovative and motivating adjunct to paediatric rheumatology rehabilitation. CLINICAL

trial registrationClinicalTrials.gov; NCT06176846.

Indexed as

Arthritis, JuvenileExercise TherapyExergamingVirtual RealityAdolescentFemaleHumansMaleMuscle StrengthPhysical FitnessPhysical TherapistsTreatment Outcomeexergamingfunctional capacityJIAphysical fitnessvirtual reality

Identifiers

PMID42384950
PMCPMC13379635

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.