Evidence map›Paper›PMID 42384916›Full record

ArticleBioinformatics (Oxford, England)2026

Meta2DB: curated shotgun metagenomic feature sets and metadata for health state prediction.

Car Reen Kok, Nisha J Mulakken, James B Thissen, Jose Manuel Martí, Ryan Lee, Jacob B Trainer, Andre R Goncalves, Hiranmayi Ranganathan, Aram Avila-Herrera, Crystal J Jaing and 1 more

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Car Reen KokLawrence Livermore National Laboratory, Livermore, CA, United States.ORCID 0009-0001-1131-9784
Nisha J MulakkenLawrence Livermore National Laboratory, Livermore, CA, United States.
James B ThissenLawrence Livermore National Laboratory, Livermore, CA, United States.
Jose Manuel MartíLawrence Livermore National Laboratory, Livermore, CA, United States.ORCID 0000-0002-1902-9749
Ryan LeeUniversity of California Merced, Merced, CA, United States.
Jacob B TrainerLawrence Livermore National Laboratory, Livermore, CA, United States.
Andre R GoncalvesLawrence Livermore National Laboratory, Livermore, CA, United States.
Hiranmayi RanganathanLawrence Livermore National Laboratory, Livermore, CA, United States.
Aram Avila-HerreraLawrence Livermore National Laboratory, Livermore, CA, United States.
Crystal J JaingLawrence Livermore National Laboratory, Livermore, CA, United States.
Nicholas A BeLawrence Livermore National Laboratory, Livermore, CA, United States.

Funding

Lawrence Livermore National Laboratory
6 · The paper itself

Abstract

summaryMeta2DB is a curated metagenomic and metadata database that provides structurally consistent microbiome taxonomy feature count tables for 13 897 samples across 84 studies, 23 disease states, and 34 geographical locations. All samples were uniformly processed using a streamlined metagenomic classification pipeline that employs a unique and comprehensive reference database indexed to contain all sequences across all kingdoms of life that were present in the NCBI Nucleotide (nt) database retrieved on 4 January 2023. This pipeline leverages high-performance computing (HPC) resources at Lawrence Livermore National Laboratory and was used to process 50TB of publicly available raw metagenomic sequence data. Extensive metadata curation was carried out through a combination of manual curation and automated parsing, producing a consistent inter-study metadata table specifically structured to facilitate training of ML models for prediction of human health. AVAILABILITY: Data is available at https://gdo-meta2db.llnl.gov/ and https://zenodo.org/records/17315984.

Indexed as

Databases, GeneticMetadataMetagenomeMetagenomicsMicrobiotaBiocurationHumansSoftware

Identifiers

PMID42384916
PMCPMC13335476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.