Evidence map›Paper›PMID 42384808›Full record

ArticleScience advances2026

Mechanical movements generated by movable lipids break endosomal barriers for enhanced mRNA therapeutics.

Zilu Li, Jie Qin, Jiayu Zhang, Yumiao Chen, Daohan Yu, Yiran Zhang, Shengfei Yang, Zhuoting Li, Juanjuan Zheng, Jinquan Cai and 3 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zilu LiState Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Pharmaceutics, School of Pharmacy, Zhejiang University, Hangzhou 310058, China.ORCID 0009-0006-1643-6222
Jie QinDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.ORCID 0009-0008-1249-9642
Jiayu ZhangState Key Laboratory of Advanced Medicals and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China.ORCID 0009-0005-3665-8431
Yumiao ChenState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan 250012, China.ORCID 0000-0002-0501-8424
Daohan YuDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
Yiran ZhangState Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Pharmaceutics, School of Pharmacy, Zhejiang University, Hangzhou 310058, China.
Shengfei YangState Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Pharmaceutics, School of Pharmacy, Zhejiang University, Hangzhou 310058, China.
Zhuoting LiState Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Pharmaceutics, School of Pharmacy, Zhejiang University, Hangzhou 310058, China.ORCID 0009-0006-8106-0460
Juanjuan ZhengState Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Pharmaceutics, School of Pharmacy, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0001-5360-2249
Jinquan CaiDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.ORCID 0000-0002-6773-3546
Fan HuangState Key Laboratory of Advanced Medicals and Devices, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Tianjin Institutes of Health Science, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China.ORCID 0000-0001-9029-8805
Jianqing GaoState Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Pharmaceutics, School of Pharmacy, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0003-1052-7060
Yu ZhaoState Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Pharmaceutics, School of Pharmacy, Zhejiang University, Hangzhou 310058, China.ORCID 0009-0000-5444-4078

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipid nanoparticles (LNPs), composed of ionizable lipids, phospholipids, cholesterol, and PEGylated lipids, have been successfully used in messenger RNA (mRNA) vaccine development. Despite substantial progress, endosomal entrapment after cellular internalization is still a critical bottleneck limiting the vaccine efficacy. While the efforts to optimize lipid p

Indexed as

EndosomesLipidsNanoparticlesRNA, MessengerAnimalsCancer VaccinesHumansLiposomesCancer VaccinesLipid NanoparticlesLipidsLiposomesRNA, Messenger

Identifiers

PMID42384808
PMCPMC13322231

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.