Evidence map›Paper›PMID 42384805›Full record

ReviewScience advances2026

Toward autonomous robotic-assisted and microrobotic surgery.

Sungyun Yang, Byung Ha Kang, Hyeongho Min, Juan P Wachs, Farshid Alambeigi, Jaydev P Desai, Pierre E Dupont, Kurt Yaeger, Katherine Anderson, Alan Kuntz and 23 more

Abstract readReview
In one paragraph

Review in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Sungyun YangDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-3728-9544
Byung Ha KangDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-6506-5118
Hyeongho MinDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Juan P WachsEdwardson School of Industrial Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-6425-5745
Farshid AlambeigiWalker Department of Mechanical Engineering and Texas Robotics, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0001-6903-5939
Jaydev P DesaiWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID 0000-0001-8298-2439
Pierre E DupontDepartment of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7294-640X
Kurt YaegerDepartment of Neurological Surgery, Houston Methodist Hospital, Houston, TX 77030, USA.ORCID 0000-0001-7520-4743
Katherine Anderson1955 Capital & K2A2 Consulting LLC (Biomedical Engineering), Signal Mountain, TN 37377, USA.ORCID 0009-0002-6243-4843
Alan KuntzDepartment of Computer Science, Vanderbilt University, Nashville, TN 37212, USA.ORCID 0000-0003-0017-3932
Ron AlterovitzDepartment of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-4492-1384
Robert J WebsterDepartment of Mechanical Engineering, Vanderbilt University, Nashville, TN 37240, USA.ORCID 0000-0003-1389-224X
Nobuhiko HataNational Center for Image Guided Therapy, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.ORCID 0000-0002-6818-7700
Janani S ReisenauerDivision of Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-8824-6691
McKenna ClinchSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID 0009-0002-0666-9736
Alex AbramsonWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID 0000-0003-4876-9751
Jie Ying WuDepartment of Computer Science, Vanderbilt University, Nashville, TN 37212, USA.ORCID 0000-0002-7306-8140
Tommaso RanzaniDepartment of Mechanical Engineering, Boston University, Boston, MA 02215, USA.ORCID 0000-0001-8362-3710
Peter C KimDepartment of Surgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
Alex S HuangHamilton Glaucoma Center, Viterbi Family Department of Ophthalmology and the Shiley Eye Institute, University of California San Diego, La Jolla, CA 92093, USA.
Cheng SunDepartment of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-2744-0896
Hao F ZhangDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-5089-1196
Cameron N RiviereRobotics Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0000-0002-6749-3140
Eric R HendersonGeisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.ORCID 0000-0002-0371-010X
Michael YipDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-9689-0172
Xiaoguang DongDepartment of Mechanical Engineering, Vanderbilt University, Nashville, TN 37240, USA.ORCID 0000-0002-9150-4014
Daniel A WollinDepartment of Urology, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-2913-0418
David H GraciasDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218 USA.ORCID 0000-0003-2735-4725
Lamar O MairWeinberg Medical Physics Inc., North Bethesda, MD 20852, USA.ORCID 0000-0001-9459-3932
Michael KarpelsonHarvard John A. Paulson School of Engineering and Applied Science, Harvard University, Cambridge, MA 02139, USA.ORCID 0000-0001-8867-770X
Robert J WoodHarvard John A. Paulson School of Engineering and Applied Science, Harvard University, Cambridge, MA 02139, USA.ORCID 0000-0001-7969-038X
Itai CohenLaboratory of Atomic and Solid-State Physics, Cornell University, Ithaca, NY 14850, USA.ORCID 0000-0001-9218-043X
Michael S StranoDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-2944-808X

Funding

Cardioscopically-guided Valve Repair in the Beating HeartR01HL124020 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Pierre E Dupont · 2014 to 2026
$9.7M
Tissue biopsying with wireless microgrippers within gastrointestinal tractR01EB017742 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI David H Gracias, Florin Selaru · 2014 to 2026
$6.6M
Dynamic Variable Aqueous Humor Outflow and Glaucoma Therapies in the Human EyeR01EY030501 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Alex Huang, Hao F Zhang · 2020 to 2026
$3.5M
Automated Planning and Robotic Delivery of Needle Biopsies under CT Image GuidanceR01CA278703 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael Yip · 2023 to 2026
$2.4M
A Novel Semi-autonomous Surgeon-in-the-loop in situ Robotic Bioprinting System for Functional and Cosmetic Restoration of Volumetric Muscle Loss InjuriesDP2AR082471 · NIAMS · UNIVERSITY OF TEXAS AT AUSTIN · PI ALAMBEIGI, FARSHID · 2022 to 2025
$2.3M
Modeling aqueous humour outfow based on digital twin of the anterior eye imaged by robotic OCTR01EY038008 · NEI · NORTHWESTERN UNIVERSITY · PI HUANG, ALEX, ZHANG, HAO F · 2025 to 2025
$1.6M
Engineering Tissue Level Targeting of Biologic Drugs via Automated Interfacial Microneedle PumpsR35GM150689 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Alex Abramson · 2023 to 2026
$1.6M
Intracardiac beating heart tricuspid valve repair via robotics.R01EB035574 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Tommaso Ranzani · 2025 to 2026
$1.1M
NCI NIH HHS R01 CA278703NEI NIH HHS R01 EY030501NEI NIH HHS R01 EY038008NHLBI NIH HHS R01 HL124020NIAMS NIH HHS DP2 AR082471NIBIB NIH HHS R01 EB017742NIBIB NIH HHS R01 EB035574NIGMS NIH HHS R35 GM150689
6 · The paper itself

Abstract

Autonomous robotic-assisted surgery (RAS) has emerged as a promising objective in biomedical technology, further enhanced by miniaturization toward microrobotic-assisted surgery (μ-RAS). This reduction in scale promises minimally invasive, partially or fully automated surgical procedures, with the potential to reduce patient recovery times, lower medical costs, and enable previously unavailable procedural options. This perspective highlights the specific advances in RAS that potentially map to the microscale (μ-RAS), organized across five surgical domains: endovascular, endoluminal, laparoscopic, ophthalmic, and orthopedic. We examine both clinical demands and technological advances in surgical robotics and identify the key innovations required for progress across these surgical fields. Our contribution is distinct in combining the perspectives of both surgical experts and bioengineering innovators, outlining a roadmap for the advancement and eventual integration of autonomous RAS and μ-RAS into mainstream surgical practice.

Indexed as

RoboticsRobotic Surgical ProceduresAutonomous RobotsHumansIntelligent Systems

Identifiers

PMID42384805
PMCPMC13322235

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.