Evidence map›Paper›PMID 42384800›Full record

ArticleScience advances2026

Annotating the pangenome reveals the diversity in the genetic basis for metabolic enzymes.

Omid Ardalani, Patrick V Phaneuf, Kalpathy J Krishnan, David Pride, Lars K Nielsen, Bernhard O Palsson

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Omid ArdalaniNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.ORCID 0000-0002-0064-3802
Patrick V PhaneufNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.ORCID 0000-0002-4122-6589
Kalpathy J KrishnanDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
David PrideDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-8161-6015
Lars K NielsenNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.ORCID 0000-0001-8191-3511
Bernhard O PalssonNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.ORCID 0000-0003-2357-6785

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Affordable sequencing has flooded public databases with bacterial genomes; yet, species-scale maps that connect gene content variation to metabolic functions essential to biotechnology/system biology remain scarce. We address this gap by building a pangenome-wide gene-protein-reaction association and applying it to 2377

Indexed as

EnzymesEscherichia coliGenetic VariationGenome, BacterialMetabolic Networks and PathwaysMolecular Sequence AnnotationEvolution, MolecularGene Transfer, HorizontalEnzymes

Identifiers

PMID42384800
PMCPMC13322260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.