Evidence map›Paper›PMID 42384784›Full record

ArticleScience advances2026

Structural and mutational insights define ERMA as the ER Mg

Manigandan Venkatesan, Michael L Oldham, Ning Shi, Adhishree Chidambaram, Neelanjan Vishnu, Abitha K Madesh, Kristen Bentz, Peter B Stathopulos, Ravi C Kalathur, Youxing Jiang and 1 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Manigandan VenkatesanDepartment of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.ORCID 0000-0003-0044-4472
Michael L OldhamDepartment of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-9672-290X
Ning ShiDepartment of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-8459-3824
Adhishree ChidambaramDepartment of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
Neelanjan VishnuDepartment of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
Abitha K MadeshDepartment of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
Kristen BentzDepartment of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
Peter B StathopulosDepartment of Physiology and Pharmacology, Western University, London, ON N6A 5C1, Canada.ORCID 0000-0002-0536-6656
Ravi C KalathurDepartment of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-4889-8003
Youxing JiangDepartment of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1874-0504
Muniswamy MadeshDepartment of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.ORCID 0000-0001-6745-9092

Funding

Magnesium flux compendium: Discover ligands, channels, and metabolic signalsR35GM145294 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MADESH MUNISWAMY · 2022 to 2026
$2.9M
Glycolytic metabolites, Calcium entry and Sjogren’s syndromeR01DE031716 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Brij B Singh · 2022 to 2026
$2.8M
Mechanisms and therapeutic potential of blocking the mitochondrial Mg2+ channel Mrs2 in obesity and NAFLDR01DK135179 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Joseph A. Baur, MADESH MUNISWAMY · 2023 to 2026
$2.1M
Structural and Functional Studies of Organellar Ion ChannelsR35GM140892 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI JIANG, YOUXING · 2021 to 2025
$1.6M
NIDCR NIH HHS R01 DE031716NIDDK NIH HHS R01 DK135179NIGMS NIH HHS R35 GM140892NIGMS NIH HHS R35 GM145294
6 · The paper itself

Abstract

Magnesium (Mg

Indexed as

Endoplasmic ReticulumMagnesiumMutationAdenosine TriphosphatasesAnimalsCryoelectron MicroscopyHumansMiceModels, MolecularAdenosine TriphosphatasesMagnesium

Identifiers

PMID42384784
PMCPMC13322241

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.