Evidence map›Paper›PMID 42384727›Full record

ArticleMolecular biology of the cell2026

The tetraspanin disc proteins, peripherin-2 and ROM1, facilitate CNG channel localization to the rod outer segment.

Molly T Thorson, Stephanie E Wei, Junseo Park, Jorge Y Martínez-Márquez, David G Ball, Jason R Willer, William J Spencer, Jillian N Pearring

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Molly T ThorsonDepartment of Ophthalmology and Visual Science, University of Michigan, Ann Arbor, MI, 48105.
Stephanie E WeiDepartment of Ophthalmology and Visual Science, University of Michigan, Ann Arbor, MI, 48105.
Junseo ParkDepartment of Ophthalmology and Visual Science, University of Michigan, Ann Arbor, MI, 48105.
Jorge Y Martínez-MárquezDepartment of Ophthalmology and Visual Science, University of Michigan, Ann Arbor, MI, 48105.
David G BallCenter for Vision Research, SUNY Upstate Medical University, Syracuse, NY, 13202.
Jason R WillerDepartment of Ophthalmology and Visual Science, University of Michigan, Ann Arbor, MI, 48105.
William J SpencerCenter for Vision Research, SUNY Upstate Medical University, Syracuse, NY, 13202.
Jillian N PearringDepartment of Ophthalmology and Visual Science, University of Michigan, Ann Arbor, MI, 48105.

Funding

VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI James D Weiland · 1987 to 2026
$17.6M
Michigan IRACDA: Training Future Professors of Engineering and PhysiologyK12GM111725 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROOKS, SUSAN V, SEPT, DAVID · 2016 to 2025
$7.9M
Understanding Photoreceptor Trafficking Pathways to the Outer SegmentR01EY032491 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jillian Nydam Pearring · 2022 to 2026
$2.2M
Training Program in Molecular and Translational Visual SciencesT32EY037212 · NEI · UPSTATE MEDICAL UNIVERSITY · PI WILLIAM J BRUNKEN · 2025 to 2026
$439k
Understanding the Role of GARP Proteins in Rod Outer Segment Disc Formation and Retinal DegenerationF32EY034760 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NAYLOR, MOLLY · 2023 to 2025
$242k
E75 IN THE DEVELOPING DROSOPHILA EYEF31EY007003 · NEI · YALE UNIVERSITY · PI SHILTON, ALYCIA N · 1999 to 2001
$14k
NEI NIH HHS F31 EY007003NEI NIH HHS F32 EY034760NEI NIH HHS P30 EY007003NEI NIH HHS R01 EY032491NEI NIH HHS T32 EY037212NIGMS NIH HHS K12 GM111725
6 · The paper itself

Abstract

The light-responsive outer segment of rod photoreceptors is composed of two distinct membrane subdomains: discs and the plasma membrane. We investigate how the disk protein peripherin-2 is engaged in CNG channel delivery to the outer segment. Instead of forming outer segments, peripherin-2 knockout (

Indexed as

Eye ProteinsMembrane ProteinsPeripherinsRod Cell Outer SegmentTetraspaninsAnimalsCell MembraneCiliaHumansMiceMice, KnockoutRetinal Rod Photoreceptor CellsEye ProteinsMembrane ProteinsPeripherinsPrph2 protein, mouseRom1 protein, mouseTetraspanins

Identifiers

PMID42384727
PMCPMC13428343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.