ArticleFolia microbiologica2026
Molecular epidemiology and clinical course of PVL-positive MRSA CC398 infections.
Article in Folia microbiologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) clonal complex 398 (CC398) carrying the lukS-PV/lukF-PV genes encoding the Panton-Valentine leukocidin (PVL) production is emerging as a concerning pathogen in the Czech Republic and Europe. This study aimed to investigate the clinical significance, epidemiology, and genetic characteristics of MRSA CC398 strains carrying the PVL genes. A total of 24 MRSA CC398 isolates were obtained from patients with skin and soft tissue infections. DNA was extracted from all isolates, and PCR amplification was used to confirm the presence of the mecA gene for methicillin resistance and the SA442 fragment for S. aureus identification. The affiliation to CC398 and the presence of the lukS-PV/lukF-PV genes were also confirmed by PCR. Sequencing was performed for all isolates to further characterize their genetic composition, including antibiotic resistance and virulence profiles. The isolates exhibited a multi-drug resistance profile, including resistance to beta-lactams and tetracyclines. Virulence factors such as immune evasion cluster genes and biofilm-forming genes were present in all isolates. These findings highlight the growing prevalence and spread of MRSA CC398 in community and healthcare settings and its ability to cause recurrent and difficult-to-treat skin and soft tissue infections. Clinicians should be aware of its presence, particularly in patients from regions where it is endemic, to enable appropriate antibiotic therapy and infection control measures.
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