Evidence map›Paper›PMID 42384287›Full record

ArticleMolecular biology reports2026

Role of epigallocatechin gallate on aluminum exposure-induced bone damage via NLRP3 inflammasome signaling pathway.

Fatma Betul Yoladi, Saziye Sezin Palabiyik-Yucelik, Zekai Halici, Elif Cadirci, Alptug Atila

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fatma Betul YoladiFaculty of Pharmacy, Department of Pharmaceutical Toxicology, Atatürk University, Erzurum, 25240, Turkey.
Saziye Sezin Palabiyik-YucelikFaculty of Pharmacy, Department of Pharmaceutical Toxicology, Atatürk University, Erzurum, 25240, Turkey. sezin.yucelik@omu.edu.tr.
Zekai HaliciFaculty of Medicine, Department of Pharmacology, Atatürk University, Erzurum, 25240, Turkey.
Elif CadirciFaculty of Medicine, Department of Pharmacology, Atatürk University, Erzurum, 25240, Turkey.
Alptug AtilaFaculty of Pharmacy, Department of Analytical Chemistry, Atatürk University, Erzurum, 25240, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAluminum (Al) residue in the ecosystem has been increasing significantly, making Al exposure inevitable. Al has been shown to inhibit bone formation and cause osteoporosis. Epigallocatechin gallate (EGCG), which is one of the primary polyphenols found in green tea, has shown positive impacts on bone health; however, its possible therapeutic role in preventing Al-induced bone damage remains insufficiently explored. The study aimed to examine the effect of EGCG on Al-induced bone damage possibly through modulation of the NLRP3 inflammasome pathway.

methodsRats were exposed to AlCl₃ to induce bone damage and treated with different doses of EGCG. Bone and serum mineral levels were determined using biochemical analyses. Relative mRNA expression levels of NLRP3, caspase-1, IL-1β, OPN, and OCN in bone tissue were evaluated by RT-PCR analysis and bone IL-1β levels were determined by ELISA.

resultsAlCl

conclusionsThese findings suggest that Al-induced bone damage may be associated with activation of the NLRP3 inflammasome pathway and that EGCG may exert protective effects, through modulation of this pathway. Thus, it was concluded that EGCG may be a promising protective agent for preventing Al-induced bone damage and may serve as a potential preventive agent for the treatment of bone diseases.

Indexed as

AluminumCatechinInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinAluminum ChlorideAnimalsBone and BonesCaspase 1Interleukin-1betaMaleRatsRats, Sprague-DawleySignal TransductionAluminumAluminum ChlorideCaspase 1Catechinepigallocatechin gallateInflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratAl toxicityBone damageEGCGNLRP3OsteocalcinOsteopontin

Identifiers

PMID42384287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.