SynthesisLangenbeck's archives of surgery2026
Evidence map of appendicitis - a living systematic review with meta-analyses.
Synthesis in Langenbeck's archives of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAppendicitis is one of the most common diseases of the gastrointestinal tract with a lifetime incidence of 7 to 9%. Appendectomy is one of the most performed emergency surgeries. Recently, non-operative treatments are emerging. It is almost impossible to keep the overview on the large and growing body of evidence on appendicitis. Therefore, the aim of this project was to create a systematic and living Evidence Map of Appendicitis.
methodsPubMed, CENTRAL, Web of Science, EMBASE were systematically and continuously searched for all published and ongoing randomized controlled trials (RCT) and systematic reviews (SR) dealing with diagnosis and treatment of appendicitis. Outcomes from every existing RCT were extracted and trial quality was assessed. RCTs and SRs on identical subjects were grouped to research topics. For specific treatment outcomes, meta-analyses were performed for all research topics with more than 3 RCTs.
resultsOut of 16373 articles screened, 527 RCTs on 104331 patients and 408 SRs were included and grouped into 74 research topics with 31 living meta-analyses. Most RCTs were from Asia (43%),followed by Europe (32%) and North America (15%). Living meta-analyses were performed for 31 out of 74 research topics. For three out of 74 research topics (4%) there were no RCT available.
conclusionThe Evidence Map of Appendicitis is the ultimate go-to source for evidence on appendicitis. Constantly updated and freely accessible via www.EVIglance.com and as mobile phone app. Clinical decision-making, evidence-based patient information are supported by the primary data provided, as well as by living meta-analyses. SYSTEMATIC REVIEW REGISTRATION: PROSPERO 2023 CRD42023482686.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.