Evidence map›Paper›PMID 42384202›Full record

ArticleMikrochimica acta2026

A tunable high-gradient magnetic separation system based on an ordered wire-array column.

Yaolong Zhang, Linyuan Wu, Yuxin Zhang, Kun Lu, Haikao Feng, Chunyi Liu, Jingyi Sheng, Ning Gu

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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yaolong Zhang *Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, China.
Linyuan Wu *Jiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School , Nanjing University, Nanjing, 210093, P R China.
Yuxin ZhangJiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, China.
Kun LuJiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, China.
Haikao FengJiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, China.
Chunyi LiuJiangsu Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School , Nanjing University, Nanjing, 210093, P R China. chunyi_liu@nju.edu.cn.
Jingyi ShengJiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, China. shengjingyi@seu.edu.cn.
Ning GuJiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, China. guning@nju.edu.cn.

Funding

Natural Science Foundation of Jiangsu Province BK20222002the National Natural Science Foundation of China 32301189the National Natural Science Foundation of China 62301351
6 · The paper itself

Abstract

Upstream sample preparation often limits the sensitivity and reproducibility of bioanalysis, particularly for rare or weakly magnetic targets. Here, we present a tunable high-gradient magnetic separation system based on an ordered Fe-Ni wire-array column, which generates stable and quantifiable local high-gradient regions under a uniform external magnetic field. The magnetic flux density (B) and volumetric flow rate (Q) can be independently adjusted, allowing separation conditions to be systematically regulated and interpreted using the Mason number (Mn). Using magnetically homogeneous metHb-RBCs and heterogeneous SPION-labeled RAW264.7 macrophages as model systems, we demonstrate tunable capture and enrichment behavior under different magnetic-field and flow-rate conditions. For metHb-RBCs, near-equal Mn conditions produced comparable captured-cell fractions across different B-Q combinations, supporting the use of Mn as a force-flow descriptor for weak and relatively homogeneous magnetic cells. For SPION-labeled RAW264.7 macrophages, OTMS-derived single-cell magnetic moment distributions showed preferential enrichment of higher-moment cells, while near-matched apparent Mn conditions gave similar enrichment trends despite pronounced magnetic heterogeneity. These results show that the ordered wire-array column provides a geometry-defined and quantitatively interpretable HGMS microenvironment for magnetic cell enrichment. The system may also provide a useful basis for future studies on other magnetic targets.

Indexed as

Cell SeparationAnimalsMacrophagesMiceNickelRAW 264.7 CellsNickelHigh-gradient magnetic separationMagnetic cell enrichmentOrdered wire-array columnTunable magnetic separation

Identifiers

PMID42384202

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