ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2026
Association between fresh frozen plasma transfusion and mortality stratified by Glasgow Coma Scale scores in isolated traumatic brain injury: a nationwide cohort study in Japan.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeFresh frozen plasma (FFP) is widely used to manage trauma-induced coagulopathy. However, its effectiveness in isolated traumatic brain injury (TBI) management remains controversial, particularly when stratified by severity based on the Glasgow Coma Scale (GCS) scores. This study aimed to examine the association between FFP administration within 24 h and mortality in patients with isolated TBI, overall and stratified by GCS on arrival.
methodsWe conducted a multicenter retrospective cohort study using the Japan Trauma Data Bank (2019-2023). Adults with isolated TBI (intracranial AIS ≥ 3 and extracranial AIS < 3) were included. Patients were classified into FFP and non-FFP groups based on transfusion within 24 h of admission. Subgroup analyses were performed by TBI severity (severe: GCS ≤ 8; mild-to-moderate: GCS > 8), craniotomy status, and FFP dose. The primary outcome was 28-day mortality. Propensity score matching was applied to adjust for confounding.
resultsAmong 12,480 patients (median age 72 years [IQR: 55, 82]; 66.6% male), 513 received FFP. After matching, FFP was not significantly associated with 28-day mortality (OR 0.80; 95% CI 0.59-1.08). In subgroup analyses, FFP was associated with higher mortality in mild-to-moderate TBI (OR 2.38; 95% CI 1.07-5.31) and lower mortality in severe TBI (OR 0.61; 95% CI 0.42-0.88). No significant differences were observed by craniotomy status or FFP dose.
conclusionsFFP administration was not associated with lower 28-day mortality in isolated TBI. Although subgroup analyses suggested the association between FFP administration and outcomes may vary according to TBI severity, these findings should be interpreted cautiously given the potential for residual confounding.
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