ArticleActa parasitologica2026
The Effect of Curcumin on Chronic Toxoplasma gondii Infection in the Testes of BALB/c Mice.
Article in Acta parasitologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
purposeToxoplasmosis is a widespread parasitic infection; it affects about 30% of the global population, either through acute toxoplasmosis or its sequels. Our aim was to determine how curcumin affected testicular infection in mice with chronic toxoplasmosis using toxoplasma gondii strain ME49.
methodsForty male BALB/c mice (6-8 weeks old) weighing between 20 and 25 g were randomly divided into four groups. The control group, uninfected animals, received 1 cc of normal saline (vehicle) for 2 weeks. Toxo infection in the Toxo and Toxo + CUR groups continued for 4 weeks. After infection, animals in the Toxo and Toxo + CUR groups were treated orally for 2 weeks with 1 cc of normal saline (vehicle) or curcumin (CUR) (200 mg/kg) respectively [1]. Levels of oxidative stress markers, antioxidant enzyme activities and gene expression, sperm parameters, and histopathological changes were measured and evaluated [1]. Levels of oxidative stress indicators, antioxidant enzyme activity and gene expression, sperm parameters and histopathological changes were measured and evaluated.
resultsToxoplasma gondii infection decreased the activity and gene expression of testosterone and serum antioxidant enzymes (SOD, GPx, and CAT), while elevating FSH and LH levels. Histological alterations, including maturational anomalies, intratubular necrosis, and inflammatory infiltration, were noted in mice infected with Toxoplasma gondii. Curcumin decreased FSH and LH levels while enhancing sperm parameters, histological alterations, and the activity and gene expression of antioxidant enzymes (SOD, GPx, and CAT), as well as testosterone levels.
conclusionCurcumin treatment mitigated testicular infection induced by Toxoplasma gondii by enhancing antioxidant enzymes, improving sperm parameters, and decreasing pathological alterations in testicular tissue.
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