ArticleRapid communications in mass spectrometry : RCM2026
Cryogen-Aided Chromatographic Purification of Millimole Quantities of Methane for Spectroscopic Clumped Isotope Analysis.
Article in Rapid communications in mass spectrometry : RCM, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Cryogen-Aided Chromatographic Purification of Millimole Quantities of Methane for Spectroscopic Clumped Isotope Analysis.Rapid communications in mass spectrometry : RCM · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
rationaleQuantum cascade laser absorption spectroscopy (QCLAS) is a fast and reliable method for analyzing the bulk (𝛿
methodsThe method employs two sequential Carboxen 1000 columns, precooled to -10°C and subsequently ramped to 150°C in two heating steps, coupled with cryofocusing on charcoal and cryocollection on silica gel. The method performance was evaluated using a well-characterized in-house methane reference gas, either diluted in air-He matrices or stored in Exetainer vials for up to 3 weeks. Purification tests on thermogenic and biogenic methane samples assessed the repeatability of the purification method across different natural gases.
resultsCooling of the GC columns to -10°C achieves complete chromatographic purification of millimole quantities of methane from contaminant gasses. The processing introduces no measurable bulk (𝛿
conclusionsChromatographic purification of millimole quantities of methane from synthetic and natural gas mixtures requires GC column cooling to at least -10°C to ensure sufficient separation from major air components. The developed method enables rapid and quantitative purification of up to 40 mL of methane without detectable isotope fractionation, demonstrating the applicability and robustness of the method for routine purification prior to QCLAS-based methane clumped-isotope analysis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.